ULCUS TROPIC UM 



218 3 



have observed it very often in beggars and in scabies patients. 

 The disease is much more common in adults than in children, in 

 men than in women. 



Histopathology. — This has been thoroughly studied by Keysselitz 

 and Mayer, and by Wolbach and Todd. The surface of the 

 ulcer is covered often by a tenacious membrane composed 

 almost solely of coarse-meshed hyahne fibrin, with detritus 

 and masses of spirochsetes and various bacteria. The fundus 



Fig. 858. — Ulcus Tropicum: Typical. 



and walls consist of granulation tissue, which does not present 

 any characteristic feature. The deeper tissues and corium 

 surrounding the ulcer present a heavy lymphoid and plasma cell 

 infiltration, and, as noted by Wolbach and Todd, numerous eosino- 

 philes are found in the vicinity of small vessels. On microscopical 

 examination of vertical sections of the ulcer, it will be seen that 

 the superficial layers of the fundus show a large amount of granular 

 detritus and numerous foci of leucocytic infiltration, while the 



