REFERENCES 



1281 



are characterized by milder symptoms and the absence of meningo- 

 encephalitis as far as is known. 



Remarks. — In Macfie's case of infection with a trypanosome 

 alhed to D. vivax, apart from sUght fever there were no symptoms, 

 and after a single injection of atoxyl the trypanosomes disappeared 

 from the blood. 



In Lanfranchi's case of accidental laboratory infection there have 

 been irregular attacks of fever lasting seven years, and general 

 debility associated with large patches of cutaneous oedema. But 

 there has been neither mental symptoms nor tremor. He has 

 been treated by atoxyl and tartar emetic. 



It will thus be seen that the trypanosome fevers resemble mild 

 infections in animals rather than human sleeping sickness. 



Diagnosis. — ^This can only be made by finding the trypanosomes 

 in the blood. 



Prognosis. — ^This appears to be good quoad vitam. 



Treatment. — ^The treatment is atoxyl administered as in sleeping 

 sickness. 



Prophylaxis. — Nothing can be said at the present time with regard 

 to this. 



REFERENCES. 



The most useful references arc the Reports of the various Sleeping Sickness 

 Commissions, Laveran and Mesnil's ' Trypanosomes et Trypanosomiases 

 (English translation, by Nabarro), and ihe Bulletins oi the Sleeping Sickness 

 Bureau, which has now become the Tropical Dis2ascs Bull. tin. A good 

 general account may be found in W. H. Hoffmann's monograph [vide infra). 



Archibald (1909). Third Report Wellcome Laboratory, p. 98. 

 Bagshawe (1913). Proc. Soc. Trop. Med. 

 Bassett-Smith (191 8). Journ. Royal Nav. Med. Serv. 



BoYCE AND Breinl (1908) . Auuals of Tropical Medicine and Parasitology, ii. i . 

 Broden and Rodhain (1909). Rapport sur les travaux du Laboratoire de 

 Leopoldville. 



Bruce, Minchin, and Sambon (1907), Proceedings of the First International 



Conference on Sleeping Sickness. London. 

 Bruce, Nabarro, and Greig (1903 and 1908). Reports of the Sleeping 



Sickness Commission of the Royal Society. 

 Castellani (1903). Journal of Tropical Medicine. 



Castellani (1903). Reports of the Sleeping Sickness Commission of the 



Royal Society, 

 Chalmers (191 8). Journ. of Trop. Medicine. 



Button and Todd (1903). Memoir XL, Liverpool School of Tropical Medi- 

 cine. 



Button and Todd (1905-06). Transactions of the Epidemiological Society, 



XXV. I. 



Button, Todd, and Christy (1904). Memoir XIIL, Liverpool School of 

 Tropical Medicine. 



Button, Todd, and Hannington (1907). Annals of Tropical Medicine and 



Parasitology, i. 161, 201. 

 Heckentroth (1916). Ball. Soc. Path. Exot., November 8. (Senegal virus.) 

 Hodges, Minchin, Tulloch, etc. (1902 and 1908). Reports of the Sleeping 



Sickness Commission of the Royal Society. 



81 



