THEJFEVER 



1135 



^^At the onset, all three types of fever are apt to be irregular, 

 because the parasites are of different ages, due to the different 

 times of inoculation, but they settle down to a regular type, possibly 



Fig. 612. — Diagram of a Temperature Chart in Simple Tertian 



Malarial Fever. 

 I, Schizont, with commencing sporulation; 2, sporulating schizont; 

 3, young trophozoite ; 4, 5, trophozoites; 6, schizont. 



because the amount of antitoxin generated is able to kill off those 

 parasites which do not conform to the age-period^of the majority. 

 Sometimes, however, two distinct broods may exist, producing 

 double fevers, or three distinct broods, causing triple fevers. 



Fig. 613. — Laverania malarics. 



Diagram showing parasites in red 

 corpuscles blocking a brain capil- 

 lary in the cerebral type of pernici- 

 ous malaria. 







I 



1 







Fig. 614. — Laverania malaricB. 



(X 250 Diameters.) 

 Photomicrograph showing para- 

 sites in situ in red blood cells blocking 

 capillaries of the brain. 



(After Norman.) 



The malarial parasite acts not merely by destroying the cor- 

 puscle in which it lives and by altering the metabolism of the 

 body by the pyretic toxin of Rosenau and his collaborators, but it 

 also has a hgemolytic toxin, first described by Casagrandi and De 

 Blasi, which destroys the red corpuscles, thus throwing more work 

 on to the liver and leading to excessive formation of bile, with, as 



