1076 



FUNGI IMPERFECT! 



Cryptococcus niger Vuillemin. 



Found by Maffucci and Sirleo, in 1895, in a pulmonary myxoma of a 

 guinea-pig. Cells in situ round or ovoid, with thick mucilaginous mem- 

 brane. White on most media; on potato brown or black. Gelatine not 

 liquefied. Said to ferment maltose. Nothing known about other sugars. 



Cryptococcus lithogenes San Felice. 

 Synonym, — Saccharomyces lithogenes San Felice. 



Found by San Felice in the lymphatic glands of an ox. Roundish cells 

 with a membrane which is at times calcified. Growths whitish on most 

 media, dark brownish after a time on potato. Gelatine not liquefied. 



Cryptococcus granule matogenes (San Felice). 



^'^nonym —Saccharomyces granulomatogenes San Felice. 



Isolated from the lung of a hog by San Felice, It grows easily on ordinary 

 laboratory media, producing white colonies. It does not liquefy gelatine, but 

 it produces slight rose-red pigment on slices of pear and on honey. 



Cryptococcus farciminosus (Rivolta and Micellone, 1883). 



Synonyms. — Cryptococcus tokishigei Vuillemin ; Lymphosporidium 

 equi Gasperini, 1908; Leucocytozoon piroplasmoides Ducloux, 1908. 



Definition.^ — Vegetative cells in situ, oval or roundish, with well- 

 marked double contour. 



Remarks. — It is often included in hypertrophied endothelial cells 

 and in leucocytes in the lesions in horses suffering from lymphan- 

 gitis epizootica in Europe, Africa, Asia, and America. 



Cultivation. — It is of difficult cultivation. Negre and Boquet 

 have used with success a medium made of agar and dried horse-dung. 

 Sugar reactions are unknown. 



Cryptococcus capsulatus (Darling, 1906). 



SynonyTn.,~~Hi stoplasma capsulatum Darling, 1906. 



Definition.— In the affected tissue the parasite appears in round 

 or oval form, measuring 1-4 microns in diameter, and enclosed in an 

 achromatic refractile capsule. Cultivation so far negative. 



Remarks.— It was found by Darling in the endothelial cells of 

 capillaries and small bloodvessels in the lungs, spleen, liver, intes- 

 tines, and lymph glands, as well as in the leucocytes. It was con- 

 sidered by Darling and others to be a protozoon, and for it the 

 genus Histoplasma was created. At present there is a consensus 

 of opinion that it is a Cryptococcus. 



Pathogenicity. — ^It is pathogenic for man, causing disseminated, 

 hyaline, pseudogranulomata in the lungs, splenomegaly, necrotic 

 areas in the liver, and ulceration of the small and large intestines. 



Cryptococcus ruber Demne, 1889. \ 



Synonym. — Saccharomyces ruber Demne, 1889. 



This organism was found in the stools of children suffering from 

 enteritis and also in certain specimens of milk. 



It grows easily on ordinary laboratory media, producing red 

 colonies. According to Casagrandi, it does not ferment any sugar. 



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