1936 DISEASES OF THE URINARY ORGANS 



URINARY TEST FOR QUININE ELIMINATION. 



At times it is necessary for the physician to be certain that quinine is being 

 absorbed by the patient, and at others that the patient is really taking the 

 quinine which has been ordered. Under such conditions a simple easy 

 iirinary test which will indicate the presence of the drug in the urine is of value. 

 Such a test can be performed as follows: — 



A. To 2 cubic centimetres of the filtered urine contained in a clean test-tube 

 add |- cubic centimetre of Tanret's reagent. This reagent is a mixture of 

 3 grammes of iodide of potash, i gramme of corrosive sublimate, and 20 cubic 

 centimetres of glacial acetic acid, in such a quantity of disti^ed water as will 

 produce in all 60 cubic centimetres. 



B. If the patient has been taking quinine, or if he has albumen in his urine, 

 the operation described in the preceding paragraph will give rise to a faint 

 opalescence or a white cloud, depending upon the quantity of either present. 



C. Next add a few drops of absolute alcohol, when the precipitate if due to 

 quinine, will disappear, while that caused by albumen will remain. 



This reaction appears in about two hours after taking a dose of quinin , 

 and will persist for twenty-four hours after a dose of 5 grains, and for forty- 

 eight hours after that of 20 grains of the drug. 



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