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INDIANA UNIVEESITY 



made between blood treated with uranium and blood to which 

 potassium cyanide had been added. 



The spectrum of cyanliLemoglobin differs but little from that 

 of oxyha^mogiobin, but a longer time is required for its reduc- 

 tion by ammonium sulphide. Perhaps the reduction of blood 

 treated with uranium may be slightly retarded, but considering 

 the difficulty attendant upon the determination of the completion 

 of the reduction process one would scarcely be justified in saying 

 that the time was prolonged. 



If a sample of methiemogiobin be made by the addition of either 

 iodine or potassium ferricyanide to fresh blood and then the mix- 

 ture be diluted to a one per cent solution, the addition of potassium 

 cyanide will at once cause the formation of cyanmethiemoglobin^^. 

 the spectrum of which very closely resembles that of reduced haemo- 

 globin. But if to a dilute solution of methiemoglobin, which has 

 been made by the addition of either iodine or potassium ferricy- 

 anide to fresh blood, there be added a solution of sodium uranium 

 tartrate, no change whatever can be made out in the spectrum of 

 the metha^moglobin. 



This seems to show that uranium does not form any combina- 

 tion with metha^moglobiu, and it certainly indicates that the ac- 

 tion of the metal is different from that of the cyanides so far as 

 the haemoglobin of the blood is concerned. The addition of diso- 

 dium tartrate does not produce any change in the spectrum of 

 normal blood. 



Conclusions. (1) The intravenous injection of a solution of 

 sodium uranium tartrate in any quantity up to the lethal dose does 

 not produce a noticeable increase in the rate of lymph flow from 

 the thoracic duct in the dog. 



(2) The rise in blood pressure produced by the intravenous 

 injection of a solution of sodium uranium tartrate into a dog is 

 of a much more pronounced and prolonged character than the rise 

 produced by injection of a corresponding cpiantity of a cyanide. 



(3) The stimulating action which uranium exercises upon the 

 respiration is vastly less vigorous than that manifested by the 

 cyanides. 



(4) The method by which uranium prevents the coagulation 

 of blood appears to be different from that exercised by most other 

 substances and probably consists in the formation of a close direct 

 combination between the metal and some one or more of the proteid 



1- Robert, Maly's Jahreahericht, 1891, 443; Haldane, Journal of Physiology, 

 1900, XXV, 230. 



