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INDIANA UNIVERSITY 



active form in the secreted lymph, for the addition of a very- 

 small amount of the drug to the lymph outside the body prevents 

 clotting. 



11:42. Blood pressure fallen about one-half. Muscular tre- 

 mors well marked but weaker than with eserine. Lymph remains 

 clear and opalescent. No noticeable increase in the rate of flow. 



11:56. Lymph still clear, no traces whatever of any blood 

 streaks. 



11:57. Injected 30 cc. of drug to kill the animal. Urinated, 

 convulsions, tremors. Slight increase and then a decrease in rate 

 of lymph flow. 



12:00. Artificial respiration stopped and animal died of as- 

 phyxia. Was still in fair condition just before death. 



In this case observations upon the lymph flow were continued 

 for only about three-quarters of an hour, but the results are per- 

 fectly typical of those obtained in other cases in which observa- 

 tions were carried on for a much longer time. In some instances 

 a very slight increase over the normal is obtained. I believe this 

 to be due not to any specific action of the drug on the formation 

 of lymph, but rather to the muscular movements of the visceral 

 organs ; and in case of convulsive contractions of the skeletal mus- 

 cles in general these probably also help to force a few extra drops 

 of lymph out of the thoracic duct or its immediate branches. The 

 increased muscular movements are probably partly due to a slight 

 stimulation of the motor endings in striated muscle. There seems 

 also to be a clearly defined but transitory stimulation of certain 

 parts of the central nervous system. This is later followed by 

 marked depression and paralysis. In a few instances slight traces 

 of blood were seen in the lymph as it flowed from the duct. In at 

 least one case the quantity of blood thus observed seemed to in- 

 crease progressively in amount as the intoxication progressed. At 

 no time, however, did the lymph acquire more than a slightly red- 

 dish tinge and the rate of lymph flow was not noticeably increased. 

 Pearce* produced edema in rabbits suffering from uranium nephri- 

 tis when he gave them 100 cc. of water by stomach daily for two 

 or three days. He assumed that the uranium had injured the capil- 

 lary epithelium and concluded that the combination of these three 

 factors, nephritis, injury to the capillary walls, and the adminis- 

 tration of water was sufficient to produce a well-marked edema in 

 rabbits. His experiments extended over a number of days, and 

 it is quite probable that in that interval pathological conditions 



^Pearce, loc. cit. 



