﻿PHARMACOLOGICAL ACTION OF URANIUM 



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with, distilled water until the desired percentage is obtained. The 

 neutralized solution is of a bright golden-yellow color. I have used 

 in nearly all cases a two per cent solution of the red oxide (UO3), 

 the percentage being based on the relation of the weight of the 

 oxide used to the amount of the solution when changed into the 

 double salt (sodium-uranium-tartrate) and completely diluted. A 

 solution made up in this manner gives no visible precipitate of egg 

 albumen, blood, or serum when added to any of these proteid 

 solutions in a test , tube. It possesses moderate antiseptic power, 

 but some fungi grow readily in two per cent solutions of it. If 

 the solution be made slightly acid it gains greatly in antiseptic 

 power, and will also precipitate proteids. Addition of a little so- 

 dium hydrate will again dissolve the proteid precipitate, which is 

 also soluble in an excess of the albumen. 



The administration of sufficient quantities of uranium to an 

 animal is usually followed within a few days by albuminuria, glyco- 

 suria, parenchyniatous degenerations, gastro-intestinal disturbances, 

 paralyses; and, according to most observers, certain marked patho- 

 logical changes are found in the blood vessels. 



Action on Lymph Flow. The effect of uranium on lymph flow 

 may best be described by the following protocol of one of my ex- 

 periments: 



Feb. IS, 1910. Dog, male, yellow, weight 18 kilos, in good con- 

 dition. Twelve hours previously the animal had eaten some meat, 

 no other solid food taken before the experiment. Etherized and 

 placed upon the pi^erating table. Arrangements made for artificial 

 respiration when needed. Blood pressure taken from right carotid 

 artery, injections made into the left femoral vein. Chest opened 

 a little at the apex and a cannula placed in the thoracic duct. 

 Normal lymph flow was 37 drops in 15 minutes, i.e., 12 J drops in 

 each five minutes. Normal time required for clotting of the lymph 

 was 4:^ minutes. Lymph was thin and somewhat opalescent, i.e.. 

 fat was present but not abundant. 

 1 11:22. Injected;, 10 cc . of a two per cent (UO3) solution of 

 sodium uranium tartrate. In the next five minutes 12 drops of 

 lymph were secreted. 



11:28. ' Injected 10 cc. of drug. In the next five minutes Ifi 

 drops of lymph were secreted. 



11:34. Injected 10 cc. of drug. Lymph flow 13 drops in five 

 ininutes. 



Lymph clotted readily after 30 cc. of drug had been injected. 

 Hence not more than traces of the uranium could be present in an 



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