1909.] 



Action of Stovaine and Cocaine, etc. 



149 



S&i L 



"illiliiiiilillilliilillliilillli 



lliillliiifill 



iiiiiiili 



Mm 



Sal 



Syiaoo 



2 Wjili! 



L 1 



ml , 



S IC /.» ^0 P5 30 irU: 



Fig. 1. — Stovaine and Cocaine. 



Simultaneous record of two sartorius muscles, R and L ; the former in cocaine /*/100<J, 

 then in saline, then in stovaine /'/lOOO and w/500, finally in saline ; the latter in 

 stovaine «/1000, then in saline, then in cocaine /^/lOOO and v/bOO, finall.y in saline. — 

 June 9, 1909. (The lecords read from left to right.) 



Thr /iirthi/l diudoguc of sfofaine or triuiethyl diinethylamino-iuethyl carbinol 

 benzoate HClC(CH:,);i CH2]Sr(CH3)2.0Bz, derived from the tertiary butyl 

 alcohol C(CH.3):iC)H, wa.s also studied. 



The sample, also supplied by Messieurs Poulenc Freres, had previously been 

 found to have an affinity value slightly above that of stovaine. 



In this case simultaneous records were made with a pair of muscles with 

 solutions of different concentrations, namely : — 



Percentage calculated as base. 



••/i/oOO methyl Stovaine 0-050 



/71000 „ „ 0-025 



VOL. LXXXII. — B. N 



