150 Comparative Action of Stovairte and Cocaine, etc. 



t 



5^500 



I .... I I .... I .... I .... I .... I 



0 5 to IS 20 25 JP m.in 



Fig. 2.— Methyl Stovaine. 



iSiiuiiltaiieous record of two sartorius muscles, K and L, the former iu ^i/500, the latter in 

 ??/1000 solution of methyl stovaine (in saline). 



As appears froiu these records, abolition took ])lace iu the following tini(\s : 

 23"5 minutes for n/1000, and 18 minutes for 7^/500; the recovery in the 

 former case was nearly complete, in the latter very incomplete. 



It appear.s that, as regards the v/./lOOO solution, methyl stovaine does not 

 differ mater'ially from stovaine, the times of abolition and degree of 

 recovery loeing almost identical. As regards tin' n/BOO soltition, though 

 the time required for abolition is rather 1-onger than might be expected, 

 the degree of recovery is (juite in accord witli tliat of stovaine. 



The general conclusion is, therefore, tbat tlie substitution of the ethyl 

 group in stovaine by the nusthyl grou]) pioduees no alteration in to.xic effect, 

 and this result is (|uite in accordance with llie aHuiity values of the two 

 substances in (juestioii. 



