Ohse7'vations on the Rate of Action of Drugs, etc. 205 



Eisenberg, Philipp, and Volk, Eichard. — 1. " Untersiicliungeii iiber die Agglutination," 



' Zeitschr. f. Hygiene,' vol. 40, p. 155, 1902. 

 Hedin, S. G. — 1. " Obsei-vations on the Action of Trypsin," ' Journ. of Physiol.,' vol. 32, 



p. 468, 1905. 2. " Farther Observations on tlie Time Relations in the Action of 



Trypsin," ' Journ. of Pliysiol.,' vol. 34, p. 370, 1906. 

 Jorgensen, Axel. — 1. " Svingninger i Blodets agglutinerende Evne ved Febris typhoidea," 



'Kliniske og experimentelle Undersogelser. Disp. Kjobenhavn,' 1904. 

 Jorgensen, Axel, and Madsen, Thorvald. — 1. "The Fate of Typhoid and Cholera 



Agglutinins during Active and Passive Immunisation," ' Festskrift ved Indvielsen af 



Statens Serum Institut,' Copenhagen, 1902. 

 Manwaring, W. H. — 1. "The Absorption of Hemolytic Amboceptor," ' Centralbl. f. Bakt. 



u. Par.,' orig. vol. 40, p. 382, 1906. 

 Morgenroth, J. — 1. " Untersuchungeu iiber die Bindung von Diphtherietoxin und Anti- 

 toxin, zngleich ein Beitrag zur Kenntniss der Constitution des Diphtheriegiftes," 



' Zeitschr. f. Hygiene,' vol. 98, p. 77, 1904. 

 Nernst, W. — 1. " Verteihmg eines Stoffes zwischenzwei Losungsmittel und Dampfraura," 



'Zeitschr. f. physikal. Chem.,' vol. 8, p. 110, 1891. 

 Schmidt, G. C. — 1. " Ueber Adsorption," ' Zeitschr. f. physikal. Chem.,' vol. 15, p. 56, 



1894. 



Observations on the Rate of Action of Drugs [Alcohol, Chloro- 

 form, Quinine, Aconitine) upon Muscle as a Function of 

 Temperature. 



By V. H. Veley, F.E.S., and A. D. Waller, M.D., F.K.S. 



(Keceived November 23, 1909,— Read January 20, 1910.) 



(From the Physiological Laboratory of the University of London, S.W.) 



Very scanty information exists as regards the effect of temperature upon 

 the activity of drugs. Brunton* says : — " That the action of veratrine and 

 of barium on muscle is very much altered by heat and cold. Many, if not 

 all, muscular poisons act^more quickly with increased temperature." 



According to the same author, Humboldtf noticed that warmth increases 

 the rapidity with which alcohol destroyed the irritability of a nerve and 

 potassium sulphide that of a muscle. Brunton and Cash| showed that " up 

 to a certain point heat increases tlie effect of veratria and cold lessens it." 

 Waller took observations of the rates of action of alcohol, ether, and 



* 'Pharmacology,' 1893, p. 45. 



t 'Ueber die gereizte Muskel und Nervenfaser,' 1797, vol. 2, p. 218. 

 X 'Journ. of Physiol.,' 1883, vol. 4, p. 1. 



