1909.] Observations on the Rate of Actiori of Drugs, etc. 211 



With one exception, the difference between the observed and calculated 

 times is about 0'5 minute, which is within the probable experimental error. 



It may be observed that the mean value of m (20'8) corresponds closely 

 with the value 20-o8 observed by Harcourt and Esson for the reaction 

 between hydrogen peroxide and hydrogen iodide. The departure from the 

 mean value of m, is + 2'5* in our experiments, which is hardly an excessive 

 variation where the reaction concerns a living tissvie. The graph of these 

 results is as under. From the mean value of m = 20'8 the coefficient of 

 increase for 10° is 2'04. 



Graph 1. 



10 20 30 to 50 60 

 Loj Io/L/ 



Fig. 8.— Alcohol, n/l. 



Chloroform. 



Chloroform, obtained from chloral hydrate, was weighed out in the 

 quantity required (1"195 grammes per 1000 c.c.) to make a solution of 

 «/100 concentration in physiological saline (omitting correction for density). 

 We took this as being the strength physiologically equivalent to that of 

 a molecular solution of alcohol.* The results were set out in the following 

 table : — 



* ' Roy. Soc. Proc.,' B, June 24, 1909. 



