240 Dr. C. Bolton. Further Observations on the [Nov. 16, 



dilated and thinned, and may contain large quantities of brown acid fluid. 

 On the other hand, the stomach may be found empty when vomiting has 

 been a prominent symptom. In the latter cases retention of food is 

 probably largely absent, as what remains is vomited. The animal may 

 discover exactly how much its stomach is capable of dealing with within 

 the physiological limits of time, so that no retention occurs. The presence 

 of diminished appetite, vomiting, and wasting are therefore not definite 

 indications of retention of food. The only tests which are of value are the 

 presence of food in the stomach a certain length of time after a test meal, or 

 the presence of dilatation of the stomach. 



IV. The Effects of Motor Insuffieiency wpon the Healing of Acute Gastric Ulcer 



in the Cat. 



The pylorus is first constricted and, after the animal has recovered and 

 settled down to a more or less definite diet, a gastric ulcer is produced as 

 described above on the anterior wall of the stomach, midway between the 

 cardiac and pyloric orifices. 



There are four groups of experiments. 



Group I. Six experiments : — ^ 

 Cat 1 : weight 2865 grammes. 



February 4, 1909. — Pylorus constricted. Tube, 9 mm. Vomited twice ; 

 appetite soon recovered and in a few days eats an average of 250 grammes 

 daily ; no vomiting. 



Fel)ruary 19. — Intramural injection of 6 c.c. serum. 



March 11. — Test meal, 120 grammes meat at 6 p.m., all eaten. Weight 

 3105 grammes. 



March 12. — Killed 9 a.m. ; stomach empty except for considerable 

 amount of liair. Acid in reaction. Scar of healed ulcer present (21s^ day) 

 (fig. 3, a). This anunal is useful as a control, as no motor insufficiency was 

 present. 



Cat 2 : died the day after the serum was injected. 



Cat 3 : weight 3700 grammes. February 4, 1909. — Pylorus constricted. 

 Tube, 9 mm. Vomited once or twice; appetite recovered, and in a few days 

 eats 100 to 150 grammes. Weight 2895 graiiunes. 



F('l)ru;ny ] 9. — Iiitranunal injection of {i c.c. scrnni. Appetite lost at first, 

 but in a few days recovered to the extent of about 130 grannnes a day, and 

 then gradually lost again, and finally eats 10 to 30 grammes a day only ; no 

 vomiting. 



Marcli 11. — Test meal, G r.M., not eaten. Weight 2500 graumies. 



„ 12. — Killed 9 A.M., Htoniach luucli dilated, wall thin and it main- 



