1909.] 



Pathology of Gastric Ulcer. 



241 



tains its shape on opening. Contains 160 c.c. brownish mucoid fluid 

 containing 0"259 per cent. HCl. Large ulcer healing, base somewhat 

 thickened and composed of granulation tissue on free surface {21st clay). 



Cat 4 : died on the eighth day after the injection ; 20 c.c. yellowish acid 

 fluid in stomach, which was not dilated. An ulcer was present about the 

 same size as that of Cat G in a sloughing condition. 



Cat 5 : weight 3610 grammes. February 10, 1909. — Pyloric constriction. 

 Tube, 9 mm. Soon recovered and appetite good. Able to eat 200 grammes 

 a day. 



February 19. — Intramural injection of 6 c.c. serum. Appetite never bad, 

 easily eats 200 grammes. Vomited once. 



March 25. — Test meal, 105 grammes, 6 p.m. Weight 4270 grammes. 



March 26.— Killed 9 a.m. Stomach distended and contained 80 grammes 

 meat and some hair. An unhealed ulcer present, the base being formed of 

 granulation tissue with a little haemorrhage from it. Base thickened and 

 omentum adherent to it. Feels like a thick nodule of flbrous tissue in the 

 stomach wall {2>Uh day) (fig. 3, b). 



Cat 6 : Died on the third day after injection ; a large perforation present. 



Group II. Eight experiments. — The pylorus was constricted in each animal, 

 and on April 28, 1909, 8 c.c. immune serum of the goat were injected into 

 the stomach wall of each. Six of these animals died within 10 days ; of these, 

 three had large ulcers, two perforated, and one had a large ulcer with 

 extensive hsemorrhagic infiltration and ulceration of the mucous membrane 

 around. 



This extensive ulceration, with or without haemorrhagic infiltration spreading 

 round the ulcer, I have found in six cases of pyloric stenosis, and never apart 

 from it. In all the cases the fluid in the stomach was neutral or alkaline. 

 Occasionally there is some oedema of the stomach wall. It is possible that 

 this condition may be due to a secondary bacterial infection owing to the 

 alkalinity of the stomach contents, but this point remains to be investigated. 

 The stomach contents, however, may be alkaline in the absence of this 

 spreading ulceration. 



Of the two remaining animals, one died on the 26th day with a large 

 unhealed ulcer and the stomach a little dilated and thinned, and the other 

 survived and was killed on the 56th day. The stomach of the latter animal 

 was not dUated and it had disposed of its test meal of 60 grammes in 

 15 hours. There was a large triangular depressed scar with some contraction 

 of the stomach at that spot. Microscojncal examination : The base of the 

 original ulcer is formed of young fibrous tissue composed of elongated cells 

 and short fibres interlacing in every direction and packed together into 



