242 Dr. C. Bolton. Further Ohservations on the [Nov. 16, 



a dense mass. The newly formed mucous membrane is directly implanted on 

 this fibroiis tissue. There is no recurving of the normal mucous membrane. 

 The newly formed glands are largely made up of cubical or columnar 

 epithelial cells, but at the base in many places central cells have been 

 formed, but no oxyntic cells. The glands mostly have distinct lumina and 

 a large number of cystic spaces has been formed, the cysts being lined by 

 flattened cells. The mouths of the glands are wide open and in many places 

 a coarsely villous appearance is given to the surface (fig. 4). A great deal of 

 cellular infiltration exists between the glands and in places projections of 

 fibrous tissue from the base cut up the mucous membrane. In some of the 

 large cysts ridges of fibrous tissue covered with epithelium project into the 

 lumina, partially dividing them into locculi. Of the controls, two died with 

 large ulcers during the first week and the remaining one was killed on the 

 55th day, showing the usual radiating scar of normal healing. 



Group III. Seven experiments. — The pylorus was constricted in each 

 animal, and on May 14, 1909, 6 c.c. imimme serum of the goat were 

 injected into the stomach wall of each. Six of these animals died within 

 five days ; of these, four had hfemorrhage infiltration and ulceration 

 around tlie ulcer, which had been produced, and in one of these cases 

 the ulceration occupied half the whole area of the mucous membrane 

 of the stomach. In each case the fluid in the stomach was alkaline 

 or neutral. Of the remaining two, one perforated and the other had 

 an ulcer of the usual size. One of the animals survived and was killed 

 on the 41st day. There was a little dilatation, and a small unliealed ulcer 

 was present. This was to some extent concealed by the surrounding mucous 

 membrane, which was very exuberant. Mrn'oseopical Examination : The 

 edges of the normal mucous membrane are turned in, the mouths of the 

 glands almost touching tlie thin epitlielium covering the liealed portion ot" 

 the ulcei'. The whole thickness of tlie stomach wall at this spot is composed 

 of dense, sclerotic, fibrous tissue, with round cells in spaces here and there. 

 In the centre is an unhealed portion occupying about one-fourth of the 

 diameter of the original ulcer. Tlie base of tliis unliealed portion is formed 

 of looser tissue, containing cells and a few dilated capillary vessels, and in the 

 centre this tissue projects and has undergone necrosis. The base of the 

 original ulcer is much thicker in the centre than at the sides. There is 

 another unh(!alcd jMji tion towards the side, about ono-foui tli the size of the 

 former, where the recurved mucous membrane touches the base of the ulcer. 

 The reformed epithelium covering the healed portion consists of a single 

 layer of cells, apparently a continuation of that covering the surface of the 

 normal cpithtjlium. The cells arc columnar in tyj)c, and as they near the 



