1909.] 



Pathology of Gastric Ulcer. 



243 



ed^es of the two ulcerated surfaces gradually become flatter and flatter till 

 they look like endothelial cells and disappear (fig. 5). The cells are implanted 

 directly upon the fibrous tissue of the base. At one spot two tiny gland 

 ducts have started to grow, each consisting of a dozen or more cells and 

 forming little depressions in the fibrous tissue, otherwise the reformed 

 epithelium consists merely of a single layer of cells. 



Of the control animals, one perforated on the 10th day and the other 

 was killed on the -ilst day and showed a small triangular scar in the 

 stomach. 



Ih-onp IV. Eight experiments. — The pylorus was constricted in each 

 animal and on June 4, 1909, 5 c.c. iimmme sericm of the goat were injected 

 into the stomach wall of each. Four of these animals died within the first 

 15 days. Of these, one perforated, one had haemorrhagic infiltration and 

 ulceration around the ulcer, and two had ulcers of the usual size. 



The remaining four cats sm'vived and all had the scars of healed ulcers. 

 Of these, two must be excluded because the stomach had been able to com- 

 pensate and no motor insufficiency developed. The remaining two, whose 

 autopsies were performed on the 52nd and 55th days respectively, and which 

 had motor insufficiency, remain to be considered. 



527id Day Cat. — The base of the scar is formed of dense fibro-cellular tissue, 

 at the outer part covered with a thin layer of atrophied muscle. The edges 

 of the normal mucous membrane are recurved and where they press on the 

 base of the scar have flattened the newly formed epithelium so that at one 

 spot it only consists of a single layer of cubical cells. The new epithelium 

 covering the scar has grown iip into glands in the centre, where it is freed 

 from pressure. The glands are formed entirely of duct epithelium directly 

 implanted on the fibro-cellular tissue. There are no central nor oxyntic cells 

 present. There is a good deal of cystic dilatation at one side where the normal 

 joins the new mucous membrane. These cysts are lined by flattened 

 epithelium. There is a considerable amount of new connective tissue 

 between the glands. 



55/^ Day Cat. — The base of the scar is not formed of such dense fibrous 

 tissue as in the former cat, and the muscular coats of the stomach have not 

 been destroyed to the same extent. The mucous membrane is thicker and 

 the glands fairly well formed, central cells are present at the base and in 

 places oxyntic cells can be seen. The glands are of irregular shapes and 

 separated by infiltration of new connective tissue. There is some cystic 

 formation of the glands. 



The two control animals both lived and showed the radiating scars of 

 normal healing on the 55 th day. Sections of one showed the mucous 



