252 Mr. Thomson and Dr. Cushny. On the Action of [Nov. 23, 



emetic. Among these the best combinations were found to be those with 

 oxyacids of the fatty series, those of the aromatic series proving much 

 less soluble. Among the salts examined were the lactate, citrate, malate, 

 and mucate, the results of which were compared with those obtained by the 

 tartrate. 



They were formed by boiling antimony oxide with the acids, and subse- 

 quently neutralising with sodium hydrate, or sometimes by forming the 

 acid sodium salt, and boiling it with freshly prepared antimony oxide. The 

 mucate, which was investigated with the idea that its multiple hydroxyl 

 groups might prove to have special powers of retaining antimony in solution, 

 miay be dismissed, as, though powerfully trypanocidal, it induced very great 

 local irritation. The citrate seemed to be inferior to the malates and 

 tartrates, which were approximately equal in value. 



Table II. — Summary of Eesults of Treatment with Sodium Antimonyl 



Malate. 



I. 



II. 



III. 



IV. 



Number of rats 

 treated. 



Number of rats that died 

 witliout recurrence, but 

 before any deduction 

 could be made. 



Number of rats surviving 

 one montli after 

 cessation of treatment 

 w ithout recurrence. 



Number of rats 

 in whicli 

 there was 

 recurrence. 



23 



9 



5 



9 



Of the rats included in Column III : One survived 241 days ; one 113 days ; 

 one 115 days; one G6 days; and one was alive and well, 235 days after 

 cessation of treatment. 



Of tlie rats included in Column IV: Eecurrence took place in 12, 11, 7, 

 17, 5, 11, 9, 36, and 10 days, and all died within two weeks of cessation of 

 treatment of recurrence (or of the last recurrence), except one wliich lived 

 231 days after cessation of treatment of the recurrence by another (h'ug 

 (Schlippe's salt). 



Among the tartrates and lualaLes, the sodium and potassium salts weie 

 equally eflicient trypanocifles, and there was no appreciable diricrence in 

 their local eCliects, but the substitution of an alkyl radical for the potassium 

 or sodium of the salt seemed to be attended with some advantage. Solutions 

 of cthylantiinonyl tartrate were kindly prepared for us by Prof. Collie by 

 heating freshly precipitated antimony oxide with ethyl tartrate, to about 

 150° C. in sealed tubes. The solutions are distinctly acid, but can be 

 neutralised or rendered slightly alkaline with ammonia, and can be sterilised 



