254 Mr. Thomson and Dr. Cushny. On the Action of [Nov. 23, 



for three weeks showed recurrence within that time, except when ethyl 

 antimonyl tartrate was employed, when the results were slightly more 

 favourable. 



In the recent report* from Uganda, the conclusion is drawn that the 

 medicinal treatment pursued up to that time had proved of little lasting 

 benefit in the great majority of even the early cases of Sleeping Sickness. 

 From this it seems a fair inference that remedies which suffice to change an 

 acute trypanosomiasis into a more chronic form may ameliorate symptoms, 

 but do not necessarily greatly prolong the natural course of a chronic 

 infection such as Sleeping Sickness. In seeking for a remedy for the chronic 

 condition, by experiments with acute infections, nothing short of an 

 immediate and complete disinfection should be the object, and it is with this 

 view that we venture to suggest the foregoing considerations. 



Applying these principles to the ethyl antimony compound, it appears to 

 comply with the first fairly satisfactorily. It expelled the trypanosomes 

 from the blood within two hours. As regards recurrence after a single full 

 dose, of 13 rats inoculated, 6 showed a. recurrence, on the 14th, 16th, 16th, 

 22nd, 26th, and 29th day. There was no recurrence in the 7 others. 



Table III. — Summary of Eesults of Treatment with Ethylantimonyl 



Tartrate. 



I. 



II. 



III. 



IV. 



Number of rats 

 treated. 



Number of rats tliat died 

 without recurrence, but 

 before any deduction 

 could be made. 



Number of rats surviving 

 over a montli after 

 treatment witliout 

 recurrence. 



Number of rats 

 in whicli 

 tliere was 

 recurrence. 



13 



0 



7 



6 



Of the rats included in Column III, one died of pneumonia on the 

 84th day, and five of the others from exposure to cold between tlie 135th and 

 165th day, leaving one survivor after 260 days. 



Of the rats in Column IV, recurrence took place after 14, 16, 16, 22, 26, 

 and 29 days respectively. 



No other drug has given such favourable results in our experiments, but 



we recognise that it will be necessary to test it against other species and 



strains and in different hosts before any general statement as to its 



usefulness can be made. 



* Quarterly Report on the Progress of Segregation Champs and Medical Ticiitmonl <if 

 Sleeping Sickness in Uganda (Quarter December 1,1907, to February 29, 19()H). 



