1909.] Antimony Compounds m Trypanosomiasis in Rats. 255 



We have also treated some rats with a solution combining the best of the 

 arsenical and antimonial trypanocides at present known to us, viz., ethyl- 

 antimonyl tartrate and atoxyl. Twelve rats were inoculated with the 

 Nagana strain, and on the third day after, when a fair number of trypano- 

 somes were present in the blood, they received a single injection of 075 c.c. 

 of a solution containing 2 per cent, of atoxyl dissolved in 0"2 per cent, of 

 ethyl antimonyl tartrate. 



Table IV. — Summary of Eesults of Treatment with Atoxyl + Ethylantimonyl 



Tartrate. 



I. 



II. 



III. 



IV. 



Number of rats 

 treated. 



Number of rats that died 

 without recurrence, but 

 before any deduction 

 could be made. 



Number of rats surviving 

 over a month after 

 treatment without 

 recurrence. 



Nunaber of cases 

 of recurrence. 



12 



2 



8 



2 



Of the rats included under Column III, two died in 31, one each in 39, 

 43, 56, 89 days, and two survived after 260 days. Thus, while the number 

 of recurrences was fewer than from the antimony alone, the combination of 

 the two drugs seemed to tend to be toxic. This was more obvious in a 

 series of 19 rats treated with a single injection of 0'75 c.c. of 3-per- 

 cent, atoxyl in 0'3-per-cent. ethylantimonyl tartrate solution. Of these, 

 11 died within 24 hours of the injection, and as the blood was free from 

 trypanosomes, they evidently succumbed to the treatment. 



Table V. — Summary of Eesults of Treatment with Larger Doses of Atoxyl 



and Antimony, 



I. 



II. 



III. 



IV. 



1 



! Number of rats 

 treated. 



Number of rats that died 

 without recurrence, but 

 too soon for any 

 deduction. 



Number surviving over a 

 month without recurrence. 



Number of cases 

 of recurrence. 



19 



16 



2 



1 



Of the two rats included in Column III, one died on the 113th day, and 

 one survived after 225 days. The recurrence noted in Column IV was noted 



