288 Dr. F. Medigreceanu. Relative Sizes of the [Dec. 21, 



weight of the alimentary canal to " body-weight less tumour " falls within or 

 near the normal ratio. It is remarkable that in most cases {cf. the figures 

 for mouse tumours, Table I, and for rat tumours, Table II), the relative 

 weight of the alimentary canal diminishes with the size of the tumour, 

 whether the latter is carcinoma or sarcoma, growing rapidly or slowly. Only 

 in 8 to 10 out of 200 cases, and then especially in animals with small tumours, 

 did the weight ratio of the alimentary canal reach the highest physiological 

 value. A hypertrophy of this organ-system could not be demonstrated during 

 the several stages of growth studied for the tumours examined. 



Liver. — The liver, on the contrary, appears hypertrophied in all cases when 

 the ratio to " body-weight less tumour " is taken. This holds for spontaneous 

 as well as transplanted tumours. A direct parallel subsists, up to a certain 



Table I. 



No. 



Age. 



Ratio : 

 tumour- 

 weiglit to 

 body- 

 weighfc. 



Digestive 

 tract. 



Liver. 



. Heart. 



Kidneys. 



Lungs. 



Spleen. 







Normal Mice. — Ratio of Organ-weight to Body-weight. 







12 



51 days 





1 : 20-8 



1 : 13-8 



1 : 148-4 



1 : 60-9 



1 : 119-3 



1 



: 81-4 



21 



3 mos. 





1 : 20-4 



1 : 12-7 



1 : 157-8 



1 : 57-9 



1 : 120 



1 



: 54-4 



18 



5 





1 : 23-3 



1 : 14-4 



1 : 168 



1 : 53-9 



1 : 121-5 



1 



: 73-3 



24 



Old 





1 : 22-7 



1 : 13-7 



1 : 159- 1 



1 : 53-9 



1 : 113 



1 



: 80-7 





Pregnant JNIice. 



— Ratio of Organ-weight to Body-weight less Foetus. 





4 







1 1 : 24-5 



1 : 10-5 



1 : 160-6 



i 1 : 60-4 



1 : 1231 



I : 



111-1 



Mice with transplanted Tumours. — liatio of Organ- 



weight to Body-weight less 











Tumour. 















A. Rapidly-growing Strains.- 



-"G3," "J," "B," " 



199." 







33 



1 3-4 mos. 



1 1:2-3 



1 1 : 22-1 



1:9-9 



1 1 : 116-1 



1 1 : 55-7 



1 : 96-7 



1 



; 43-6 



43 



i 3-4 „ 



1 1:3-3 



1 1 : 21-2 



1 1 : 11-0 



1 1 : 138-1 



1 1 : 56-5 



1 : 101-8 



1 



: 62-4 







B. Iiitennediato Strains. — " 



50," "39," " 100," " 



92." 







10 



1 3-5 „ 



1 1 = 2 



1 : 21-7 



1 : 10-1 



1 : 118-7 



1 1 : 53-3 



1 : 83-4 



1 



: 53-3 



27 



1 3-5 „ 



1:3-6 



1 : 19-8 



1 : 101 



I : 125-7 



I 1 : 52-8 



1 : 1 10-3 



1 



: 48-9 







C. Slowly-growing 



Strains. — 



" 62," " T, 



" " 93 " " 



173." 







9 



3i-6 „ 



1 : 1-7 



1 : 20 0 



1 : 9-2 



1 .- 128-8 



1 : 54-1 



1 : 119-5 



1 



: 50-3 



27 



3i-6 „ 



1 : 4-0 



1 : 18-3 



1 : 10-9 



1 : 123-3 



1 : 53-0 



1 : 108-1 



1 



: 36-5 







Mice with Spontaneous Carcinomuta. 









1 



Old 



1 : 1-4 



1 : 25-0 



I : 8-9 



1 : 114-5 



1 : 53-8 



Metastases 



1 



: 56-3 



1 



»> 



1 : 3-5 



] : 25-1 



I : 7-3 



1 : 128-] 



J : 61 



11 



1 



: 40-2 



1 



II 



1 : 3-0 



1 : 23 2 



1 : 9-9 



1 : JOl-4 



1 : 56 



II 



J 



: 54-7 



1 



It 



1 : 3-6 



1 : 23-5 



1 : 10-0 





1 : 55 



II 



1 



: 44-1 



