292 Relative Sizes of the Organs of Hats and Mice, etc. 



(1) No increase in weight of the alimentary canal as compared with 

 normal ratios. 



(2) Hypertrophy of the liver in all cases. Up to a certain point the 

 hypertrophy is proportional to the weight of the tumour. 



(3) Hypertrophy of the heart in most cases. This also is in general 

 proportion to the size of the tumour. 



(4) Kidneys of normal weight except in the case of a transplantable rat 

 sarcoma in which hypertrophy is produced. 



(5) Varying ratios for the lungs. 



The most important result of the investigation has been the discovery of 

 an enlargement of the liver, in animals bearing carcinomata and sarcomata, 

 whether transplanted or naturally arising. The nature and causation of this 

 hypertrophy is being further investigated. It would be natural to seek an 

 explanation in an increased assimilation of food through the alimentary 

 canal. The results show an absence of a corresponding hypertrophy of the 

 digestive tract for tumour animals. Histological studies have not, so far, 

 indicated any clear anatomical changes. In a future paper the hypertrophy 

 of the liver will be considered from the standpoint of the intalce and 

 elaljoration of food material from the intestinal canal, and of the excretory 

 functions of the liver. The possibility will be considered of the circulation 

 of abnormal products given off l)y the tumour, and the possibility that the 

 liver may elaborate abnormal products to meet the special needs of the 

 tumour. 



