298 Drs. Bashford and Russell. Homogeneity of [Jan. 17, 



The reaction which introduction of disintegrated cells calls forth is not 

 only quantitatively different from that induced by living tissues, but also 

 qualitatively diff"erent. Far from inducing any increased resistance, inocu- 

 lation of disintegrated cells only seems to manure the soil for a subsequent 

 growth of tumours. 



The failure to elicit the reactions of immunity to the transplantation of 

 cancer by devitalised tissues reveals an important difference from the immunity 

 reactions obtained against bacteria and their products and foreign proteids in 

 general, in which cases the immunising properties are independent of the 

 vitality of the organisms or cells. 



FurUte?' Evidence on, the Homogeneity of the Resistance to the 

 Implantation, of Malignant New Groivths. 



E. Y. Bashfoed, M.D., and B. K. G. Russell, M.D., Imperial Cancer 



Research Fund. 



(Communicated by Prof. J. Rose Bradford, Sec. R.S. Jieceived January 17, — 



Read February ;3, 1910.) 



This paper is based mainly on a study of the processes at the site of 

 implantation of a malignant new growth when a secondary implantation is 

 ])raf!tised on mice already bearing transplanted tumours. New evidence will be 

 adduced supporting tlio view that concomitantly with the establishment of 

 such tumours, an active resistance may l)e iiiduccHl by the absorption of 

 tumour tissue. When a secondary inoculation fails, this failure is due to an 

 active resistance to the cancer cells introduced, similar to that induced in 

 normal animals by the absorption of tumour tissue or normal tissue of the 

 .same species. The process consists essentially in tlu; cancer cells failing to 

 elicit the specific connective tissue and vascular scallblding necessary to their 

 (!stal)]ishing themselves and growing into a tumour. In order to simplify still 

 further prevailing conceptions of the process of immunity to cancer, we shall 

 record corresponding observations on rats where the ])i'imary inoculation of a 

 mouse (jarcinoma lias boiui followed by a secondary inoculation of mouse 

 tumour. 



]n the First Scientific Repoii, of the Imperial (JauctT Ktisenrcb Kiiiid 

 (March, 1904) it was staUjd " in \\w light of th(! jjlieiionicna of inniiunil.y, it is 

 interesting to note that it is possible* to ol)taiii multiple tumours from tnuis- 



