334 Drs. V. H. Veley and A. D. Waller. Action of [Feb. 22, 



(3) A subsequent increase of contraction up to, or even beyond, its original 

 value, the muscle remaining throughout in the nicotine solution. 



(4) A final gradual decline of contraction. 



Typical records are as under ; the " type " is characteristic and reproduces 

 itself in all our records. 



N, 



Fig. ]. — Nicotine tai trate, O'Ol per cent, (ft/1620 as base) ; at Nj a solution of nicotine 

 tartrate, O'Ol per cent., is run in. The typical effect (twitching, contracture, and 

 primary diminished contraction, giving way to increased contraction) is well marked. 



t t 



N, N, 

 Fig. 2. — Nicotine tartrate, O'Ol per cent, at N,. Excitation suspended from this point to 

 the next, so as to allow the contracture and twitching to be uncomplicated by the 

 eflects of excitation ; the subsequent increase of contraction is well marked. O'l per 

 cent, at Nj gives no marked effect. 



Fig. 3.— Nicotine >(/1000 (O'OlfJ jjer cent.). 



Other records (not here reproduced), taken at various strengths of solution, 

 were so much alike as to be hardly distinguiahal)le apart, and altogether 

 different from the records obtained with any otlier drugs. 



