342 Drs. V. H. Veley and A. D. Waller. Action of [Feb. 22, 



produce abolition of contraction in half an hour, yet, in the mixed solution 

 curarine in 1/40 of that mass, altogether effaces the effect of nicotine. 

 This is a very striking case of antagonism, and as regards the proportion 

 between the antagonistic reagents we have understated it. 



Fig. 9. —Complete abolition of the typical nicotine effect by curarine iodide, N/C = 31/1. 



Fig. 10. — Almost complete abolition of tlie typical nicotine eftect by curarine iodide, 



N/C = 1(50/1. 



Taking the mixed solution with curarine at five times the dilution, 

 i.e. with curarine at m/85000 and nicotine as before at ?«/500, there is still 

 a very considerable if not absolutely complete abolition of the characteristic 

 nicotine effect. In this case the proportion by molecules is IGO : 1. 



That this antagonism is of a peculiar, and, so to si)eak, specific character, 

 is borne out by experiments with other drugs, where we find that far 

 greater proportional mass is required for the abolition of the characteristic 

 nicotine effect. 



We have tested in this connection the inlluence of cinchonamiue. 

 Taking, e.f/., a mixture of nicotine at »/1000 p/M.s cinchonamine «/2000, we 

 obtained a record exhibiting the characteristic effects of nicotine and 

 cinchonamiue, but in which the nicotine effect was less in th(! ])ivsence 

 of cinchonamine than it would h;iv(! hvvn in its absence, and in which the 

 cinchonamiue effect was lessened by the- nicotine. This appears to us to 

 indicate a state of sulxlivision, the nniscle stuff being conjointly occupied 

 by the two bases, nicotine and cinchonamiue, as in the ordinary case of 

 subdivision of an acid between two bases ; but the case of nicotine and 

 curarine cannot be brought under the same category. 



We have also tested mixtures of nicotine and strychnine, with proportions 



