348 The Origin of the Hydrochloric Acid in the Gastric Tuhides. 



the free (ionised) or in the " masked " (un-ionised) condition, it is not always 

 secreted into the canaliculi. In some cases, notahly in certain rabbits, it 

 was liberated only on the surface of the cell remote from the lumen of the 

 tubule. In this case there was no blue deposit in the lumina of the tubules 

 or in the canaliculi of the parietal cells, but in the lymph capillaries imme- 

 diately adjacent to the tubules there was a blue granular deposit which 

 revealed the course of the capillaries. The lymph cells in the course of 

 the larger channels also contained in their cytoplasm a blue granular 

 deposit. Sometimes, further, the contents of the blood capillaries in such 

 preparations here and there gave a blue reaction. The explanation which 

 may be advanced for these results is that the cytoplasm of the parietal cells, 

 perhaps under the toxic effect of the potassium ferrocyanide, has lost some of 

 its osmotic properties and the direction of elimination of the acid is changed ; 

 in other words, the parietal cells in this case have, as it were, lost the sense 

 of direction. 



The observations briefly summarised here will, with others of a cognate 

 character, eventually appear in a more complete communication. 



