1910.] 



AulotoxcEniia and Infection. 



533 



Chart 4. — Babbit. (Control.) 

 A 



DAY 

 HOUR 

 C* F- -4 

 •2 



39-6 



^ ° 103 0 

 ■8 

 •6 

 •4 



390 -2 

 102-0 

 ■8 

 •6 



■4 

 ■2 



38-5 



CAY 

 HOUR 

 C F'-4 

 •2 



39-6 ^ 

 103-0 



•8 



390 -2 

 102-0 

 •8 

 •6 

 ■4 



38-5 



1 









2 













3 



















4- 

















5 



6 



1 



6 



8 



10 



10 





2 



5 



8 



10 



10 



II 



la 



1 



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1 



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A 

















A 







A 













i 



































































































V 

































































































































































































B 



1 





1 



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I 



6 



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10 



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5 



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10 



II 



12 



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=v 























































V- 



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Experiments. 

 The results of injection of water were as follows : — 



A. On Tcmperahire. 

 1. Single Injections.— Sixty guinea-pigs, varying in weight from 100 to 

 600 grammes, were injected under the skin of the abdomen with single 

 injections of boiled distilled water, in quantities varying from 1 c.c. to 10 c.c. 

 A rise of temperature was observed in 50. It has so far not been possible to 

 establish a constant between the bulk of injection, the weight of the animal 

 injected, and the degree of fever produced. A marked rise has occurred after 

 injection of a quantity of water equivalent to 1/304 of the body weight. The 

 rise in temperature after single injections is rapid and fugitive. It attains its 

 maximum in from 2 to 5 hours. A rise above 103° F. or 39-5° C. after first 

 injections is exceptional, and is often less. The rise is easily missed unless 

 repeated observations are taken, at least once an hour. Twelve rabbits 



2 s 2 



