1910.] 



AutotoxcBmia and Infection. 



543 





Animal 1a. 



Animal 1b. 



Animal 2a. 



Animal 2b. 





3. 15^^ 



3 "15 



3.16f 



3. 154 



trypsin 











First reading,6ininutes after addition 



2. 504 



2. 514 



2.51| 



2.514 



of trypsin 











Second reading, 35 minutes after 



2. 39 



2.39 



2. 394 



2. 39 



addition of trypsin 











Tliird reading, 65 minutes after 

 addition of trypsin 



2.30| 



2. 30f 



2. 304 



2. 304 



Fourtli reading, 95 minutes after 



2. 274 



2. 27 



2. 27| 



2. 27f 



addition of trypsin 









The difference between the means of the two duplicates of the two serums 

 is not in excess of three-fifths of a second, once digestion has begun. 



Comparison of the following curve (p. 544) with the preceding curve 

 illustrates the gross resemblance that exists between the curves of animals 

 that have received injections of water only, and of those that have been 

 artificially infected with bacterial products. 



A guinea-pig of standard weight was injected on Saturday, October 23, 

 1909, at 10 A.M., with 0-91 of a M.L.D. of diphtheria toxin. On the following 

 Monday, at 10 a.m., he was killed, and the antitryptic value of the serum 

 estimated the following day. Estimations in duplicate. Temperature, 12° C. 

 throughout. 





Control 1a. 



Control 1b. 



Injected 

 animal 2a. 



Injected 

 animal 2b. 



First reading, 1 5 minutes after addi- 



2. 284 



2. 28f 



2. 294 



2.29i 



tion of trypsin 







Second reading, 45 minutes after 



2.214 



2. 21| 



2.24f 



2. 2A\ 



addition of trypsin 







Third reading, 75 minutes after 



2. 16a 



2. 16| 



2.20f 



2.20 



addition of trypsin 









Fourth reading, 135 minutes after 



2.13 



2.13^ 



2. 17-1 



2. 17 



addition of trypsin 









