544 Autotoxoemia and Infection. 



Viscosity Curve showing Antitryptic Power of Serum after Injection of Diphtheria Toxin. 

 150 



/45 

 135 



130 



0 15 30 45 60 75 90 105 120 135 150 

 Minutes 



A, Serum of control animal, mean of duplicates. 



B, Serum of injected animal, mean of duplicates. 



Conclusions. 



These experiments show that, as regards gross results, there is a close 

 parallelism between : — 



(1) The temperature charts of animals that have received injections of 

 water and of those that have received injections of living bacteria, or of 

 solutions of bacterial toxins. 



(2) The weight curves of animals that have received multiple injections 

 of water and of those that have received injections of living bacteria, or of 

 solutions of bacterial toxins. 



(3) The antitryptic values of the serums of animals that have received 

 multiple injections of distilled water, or of solutions of bacterial toxins. 



'J'luiy lend strong support, in fact, to tlie view I have already advanced,^ 

 based on clinical observation, that however great the share taken by micro- 

 organisms, including ])rotozoa, and tlieir products in initiating the disease 

 complex of inlection, the net result is, perhaps to a large extent, a state of 

 true auto-intoxication. 



Note. — The only observations on the effect of sul)cutaneous injection of 

 small (ju.'uitities of (UstilliMl water as regards the production of fevci' that I 

 can find ill the literature are those of Krehl 'in 1897, who S[)ecifically denies, 



