Inoculation for Pleuro- Pneumonia in Cattle. 253 



as possible, and also that it should not come from a lung " over 

 diseased ;" for which purpose we caused an animal to be killed 

 in the early stage of Pleuro-pneumonia, so that no untoward result 

 might arise from a neglect of these precautions. We were 

 assisted in these operations by Mr. H. Pyatt, veterinary surgeon, 

 Nottingham, who is consulted by Mr. Paget in all cases requiring 

 medical care, and who took a deep interest in these experiments. 

 Mr. Pyatt also kindly undertook to watch the progress of events, 

 and report to us as occasion seemed to require. 



It was decided to leave fourteen of the inoculated cows to 

 mingle indiscriminately with the rest of the herd, but to remove 

 two of them to an infirmary shed, into which diseased animals, 

 as they were attacked, were taken, so as to expose them to the 

 more direct influence of the contagion. This experiment was 

 continued for several weeks, when it was discontinued, the animals 

 during the time remaining unaffected. 



With two exceptions the inoc\x\di\ioi\ failed to produce the slightest 

 effect ; and in these two animals it was not until the ffteenth day 

 of the operation that the wounds inflamed. In consequence of 

 this failure we determined to re-inoculate the cows, which was 

 accordingly done on December 13th. Twelve only out of the 

 fourteen were however operated upon, two being left to see if the 

 previous inoculation would still take ; Dr. Willems, in his 

 Memoir, having stated that a month sometimes elapses before 

 any local effects are observed. No such phenomenon occurred 

 in either of the cases, but, nevertheless, as one of these cows, 

 after inoculation, was a little out of health for about a week, 

 and both Mr. Paget and Mr. Pyatt thought this might possibly 

 depend on the inoculation, it was determined not to repeat the 

 operation upon her. This cow, up to the present time, June 1st, 

 1853, has continued well. This cannot but be considered as a 

 decided instance of a W(9?i-inoculated animal resisting for months, 

 equally with those which were inoculated, the contagious influ- 

 ence of Pleuro-pneumonia ; for the continental authorities affirm, 

 and in this we fully agree, that no constitutional effects can 

 result from inoculation unless local morbid action is first pro- 

 duced. With regard to the other cow, she was subsequently re- 

 inoculated, and lost her tail from the gangrenous inflammation 

 which attended the operation. 



On one of the two original cases successfully inoculated, as 

 it is ordinarily described, the inflammation was succeeded by 

 ulceration of the parts adjacent to the puncture. It was feared 

 that the animal's tail would be lost ; such however did not prove 

 to be the case. Further particulars, both with reference to 

 this last-named cow, and also the re-inoculations, will best be 



