Inoculation for Pleuro- Pneumonia in Cattle. 255 



to show itself among the animals on the farm, and carried off 

 no less than seven of them — six zzow-inoculated and one in- 

 oculated. The inoculated cow was, however, one of those 

 which had been operated on by " a first remove^'' on December 

 19th — No. 21. She was observed to be ill on the fifth day 

 succeeding the operation, and an examination showed her to be 

 the subject of Pleuro -pneumonia. The disease advanced so 

 rapidly that by the fourth day of her illness it was deemed 

 prudent to have her destroyed. The autopsy confirmed the 

 correctness of the diagnosis. Mr. Pyatt writes that the right 

 lung weighed 30 lbs. 



Presuming inoculation does give security, this case must not 

 be ranked among the exceptions or failures, for there cannot be a 

 doubt that the animal was affected with Pleuro-pneumonia, in 

 its incubative stage, at 'the time she was inoculated. It should 

 be noted, however, that the inoculation took effect upon a diseased 

 animal, and that its local action was in no way modified thereby ; 

 facts totally at variance with the established laws of inoculation 

 for diseases which are daily propagated in this manner. The 

 question of inoculation proving abortive as a means of protection, 

 because it was one of " a first remove," cannot be raised in this 

 particular case, as it has been in others, from the facts connected 

 with the time of the animal's illness. With regard to the 

 point of non-protection from this manner of inoculation, we may 

 remark that No. 10, operated upon the same day with No. 21, 

 and likewise the four cows previously made mention of as being 

 also inoculated by " a first remove," have now been several 

 months on the premises without giving any evidence of disease. 

 In this particular they agree with those inoculated directly 

 from the lung ; hence we may infer, that, if one is protective, so 

 is the other. This point, however, will present itself for our 

 examination again in the sequel of this Report. 



From the fluid obtained from the lung of No. 21 it was 

 arranged to inoculate more of the herd, and accordingly the 

 animals occupying " Shed 14" were fixed on. j 



Mr. Pyatt, in his report of the experiment, says, " that the 

 inoculation, which was done the same in all, on December 29th, 

 produced considerable effect on six of the animals, very little on four, 

 and none on the remaining four. Notwithstanding these variable 

 results, the experiments upon the whole were deemed to be 

 sufficiently satisfactory to warrant the continuance of inoculation, 

 and Mr. Paget accordingly determined that such should be done. 

 On January 12th he wrote to the following effect : — 



" I am inclined to think that inoculation is protective, for we have had in 

 the fifteen hovel two cases of Pleuro-pneumonia out of three non-inoculated 

 animals, while the remaining twelve, all of which had been inoculated, have 



