256 



Inoculation for Pleuro- Pneumonia in Cattle. 



escaped, with one exception. This exception is No. 21, which received the 

 virus from another cow's tail. I think it will be best to inoculate several 

 newly-purchased animals, for it is something to have protection, even if it be 

 but temporary." 



(Signed) Charles Paget." 



The inoculations were continued from this period to the end 

 of February, with slight interruptions, by which time all the 

 animals, amounting to about one hundred, were inoculated. 



The extension of the inoculation was accompanied by a marked 

 reduction in the number of the cases of Pleuro-pneumonia. 

 During January three animals died of the disease, two of these 

 being i^/i-inoculated ; the other inoculated, but only on the day 

 preceding her illness. For practical deductions this animal 

 must be viewed as a ?zc7z-inoculated one. In the month of 

 February four cows sank from Pleuro-pneumonia ; two of these 

 had been inoculated and two not. In March a year-old bull 

 died. This case will be presently explained. April passed 

 without a death, but May has furnished us with three deaths, 

 and all in inoculated animals.* As in by far the larger number 

 of these cases the local effects differed but little from those which 

 have already been described, it is unnecessary to enter into the 

 details, but a summary of the whole is required. 



The inoculations, with the exception of the six " first removes " 

 previously described, were all made with the serous exudation 

 of a diseased lung. In the major number of instances the in- 

 oculation took the first time, that is, slight effusive inflamma- 

 tion succeeded by suppuration followed the operation ; other 

 animals required a second, and a few a third inoculation to pro- 

 duce these effects. 



Five cows completely resisted the inoculation, having been 

 operated on many times at various intervals, without the slightest 

 effect. 



In one case no evidence of the inoculation was observed for a 

 month ; and it is worthy of observation that thrice during this 

 time this animal was out of health, and required medical treat- 

 ment ; at the end of the month the tail became inflamed, and 

 swelled to the size of a man's arm. The inflammation ended in 

 ulceration and sloughing of the skin, but the organ was saved. 

 This case is also the more remarkable, as, in all other instances 

 where the inflammation has run high, the action has quichly 

 followed the operation. 



* A letter received this morning, June 1st, from Mr, Paget, states that *' another 

 cow, making the third, has been killed, having the complaint without doubt. She 

 was of the second batch of inoculated subjects." At the close of his communica- 

 tion Mr. Paget says, "I hope, however, you will feel justified in recommending 

 further trials of inoculation, for I cannot doubt that I have derived great benefit 

 from its use." 



