14^ On Vaccifiation, [Fbw, 



It was observed at the same time, in some villages in the 

 sieighbourhood of London, where the smail-pox was epidemic, 

 that eruptions appeared anew, as attendants of vaccination. The 

 same thing was observed at Ketley, in Shropshire, in a house 

 where there were a considerable number of persons inoculated 

 with the small -pox.* 



Finally^ Dr. Jenner in a letter to Dr. Marcet, dated 25th 

 February, 1803, affirms that out of 10,000 persons inoculated 

 in England by himself and his nephews, not a single person had 

 been afflicted with eruptions.f 



In 18073 t^^^ report of the Royal College of Surgeons in Lon- 

 don aoDOunced, that out of 164,381 vaccinations, 66 persons 

 only had shown any eruptions. This is in the proportion of 1 

 to 2490-(>. t 



These observations made in England are confirmed by simi- 

 lar observations made in other countries. 



When the practice was introduced into Denmark, eruptions 

 were perceived which afterwards disappeared. § 



The same thing* was observed at Hanover and Geneva. The 

 observations made at Geneva deserve particular attention. It 

 was in 1800 and 1 801, while the small-pox was epidemic, that 

 eruptions were first perceived during the course of vaccination. 

 Afterwards they disappeared ; but in 1808 the small-pox con- 

 tagion was introduced again. The eruptions after vaccination 

 made their appearance a second time. Since that time they have 

 not been observed. || 



One of ourselves observed the same thing at Lucca in the 

 month of July, 1806. The small-pox was epidemic, and among 

 the children vaccinated at that time several had eruptions, which 

 were not perceived aftervv-ards.*^ 



In the correspondence of the Society formed at Paris, there 

 are examples of sporadic eruptions ; and the number of cases in 

 which they appeared bears no proportion with the cases of vac- 

 cination practised in the empire. That quantity from the last six 

 months of 1S04 to the end of 1810 amounts to 2^671,661 vac- 

 cinations, ft 



The nature of the eruptions observed has been very variable. 

 In general the pocks resembled those of the chicken-pox rather 

 than those of the small-pox. Some have resembled the cow- 



* Bibl. Brit, vol, xy. p. 371. 

 i BIbl. Brit. toI. xxv. p. 182. 

 J Bibl. Brit. yoI, xxxvi. p. 371. 



§ Dr. Jetiner's letter to Br. Marcet, Bibl. Brit. vol. xxv. p. 182. 

 li Odier Bibl. Brit. vol. xx, p. 214 ; xxxix. 91, 93, 94: x!v. 64, 65. 

 ** Memoir of the Class of Physical and Mathematical Sciences of the Institute, 

 vol. viii. p. 21. 



+ f Notes communicated to the Secretary of the Society established -at Pari^ 

 for the extinction of the small-pox. 



