MANGE. 



581 



chosen places are the head, the guttural and cervical regions, and 

 the inner aspect of the legs. 



At the beginning of the j)rocess the skin is tumefied, red, and 

 hot ; the hair is erect ; so-called miliary buttons appear, which are 

 soon transformed into reddish or whitish-blue pustules. The in- 

 tegument may acquire double its normal thickness ; it is covered 

 with a greeuish-yellow, viscous, purulent, and bloody exudate, and 

 also with dry yellowish or reddish-gray scabs. The hairs which 

 are still upon the diseased regions may be torn out by the slighest 

 traction ; their roots are coated with a layer of pus. When the 

 skin is folded or slightly compressed, blood or purulent masses will 

 ooze out of it. The intensity of pruritus varies according to the 

 individuals : at times it is very severe, but in most cases it is 

 almost wanting ; as a general rule, it is much less marked than in 

 sarcoptic mange. 



When, later, the objective manifestations of the disease are not 

 modified by scratching or rubbing, the skin dries up, becomes 

 wrinkled, and covered with lead-gray epidermic matter or scabs, 

 between which bloody cracks and crevices are formed ; it takes the 

 appearance of the bark of a tree or of elephant skin ; it is some- 

 times strewn with hard pimpled projections. The non-pigmented 

 regions are of a red or coppery shade, or appear as a rosy ground 

 strewn with red- blue pustulous pimples (whence the old denomina- 

 tion, " red mange Lastly, we may also observe in some loca- 

 tions small circular depressions and papillary or connective tissue 

 vegetations. The patients are thin and sensitive to cold, their ex- 

 pression is much altered, and the head reminds one of that of the 

 hippopotamus. The general condition, however, is hardly dis- 

 turbed ; the appetite is ordinarily increased, and in some instances 

 we may observe a true " hunger-evil " (the central organic changes 

 being increased as a consequence of the cutaneous irritation). 



These symptoms may be greatly modified when the animals 

 scratch or rub themselves. The diseased surfaces are then trans- 

 formed into suppurating wounds or large ulcerations. The inflam- 

 matory œdema of the subcutaneous connective tissue produces 

 enormous tumefactions in some regions — on the head, in the neigh- 

 borhood of the eyes, upon the neck, etc. The animals in which 

 the disease has reached the degree of marked emaciation spread a 

 particular odor, perceptible at some distance, and have a miserable 

 appearance. They soon die from exhaustion or septicemia. 



