130 



H. F. Formad, 



What has been said of the cat seems to hold good for all other 

 non -scrofulous animals as far as I could trace it. The connective 

 tissues of scrofulous and non -scrofulous individuals bear exactly the 

 same relation to one another as the connective tissue of the rabbit 

 bears to that of the cat. — 



I beg leave to describe now in short how the two tissues (from 

 non-scrofulous and scrofulous animals) behave if they become the seat 

 of ordinary inflammation. When a part in a non -scrofulous normal 

 subject or animal is the seat of an acute inflammation, it is solely in 

 the connective tissue, with its pertaining lymph -spaces and blood- 

 vessels, that the inflammatory process makes its active display. Under 

 the microscope all the lymph -spaces of the affected area are seen 

 filled with cells ; often they are enormously distended by them , so 

 that the whole appears like a sponge soaked with a corpuscular liquid. 

 Whether the cells invading the tissue are desquamated and proliferated 

 endothelium of the lymph -spaces, or whether they are wandered -in 

 corpuscles, or both, we will not discuss here. They do not stay there 

 long, however, under ordinary circumstances; they are bound to leave 

 the tissue they invaded (resolution), or they must die together (sup- 

 puration), forming loss of substance. In either case, particularly in 

 resolution, it is the office of the lymph-spaces to relieve a part of the 

 exudate, and they are the means which promptly, and in due time, 

 effect the carrying off of the mischievous and intruding cells; thus 

 accomplishing the return of the tissue to the normal state. This will 

 only occur, however, if, and as long as, the lymph- spaces are not 

 obstructed and will allow the free intercommunication of serum between 

 the blood-vessels and the lymphatics, which is so essential to the well- 

 being of the organism. 



If, on the other hand, a part in a scrofulous subject or animal 

 becomes the seat of inflammation, the termination of the latter will 

 be an entirely different one. The connective tissue is here at fault; 

 its lymph -spaces, which are narrow and obliterated, do not permit 

 the reabsorption of the exudate, and the tissue of the affected area 

 suffers under the voluminous pressure of the imprisoned cells, which 

 form a permanent lymphoid infiltrate, — the tubercle granulation. 

 This dies, — i e., undergoes cheesy degeneration. The cheesy mass 



