ii8 



and painful to the touch. On the 7th day a pea-sized fungoid ulcer 

 appeared at the inoculated place on the right side of the septum. 

 On the nth day appeared a pearl-cord-swelling arising from the 

 intermaxillary space, which was then much swollen, extended 

 over the maxillar border to the masseteric region, and showed 

 partial fluctuation. On the 12th day the abscess opened of itself 

 and evacuated abundant pus. After that the swelling and nasal 

 discharge diminished day by day and the case terminated in 

 complete recovery. 



After the third inoculation, there was, for some time, only 

 mucous discharge from both nostrils ; 31 days after the inoculation 

 appeared at locus itioailatioiiis a big fungoid and many smaller 

 similar ulcers, and a transparent mucous discharge from both 

 nostrils. On the 65th day the ulcers became confluent, forming 

 an extended ulcer, 2 inches in diametre. On the 115th day many 

 minor ulcers appeared around the chief ulcer, which was then 

 much enlarged ; nasal discharge stopped, and a pea-sized 

 ulcer and a hazelnut-sized nodule appeared at regie buccalis, 

 close to angulus oris dexter. After that time the morbid process 

 became regressive ; on the 184th day the animal was apparently 

 recovering. On May nth the horse was destroyed and dissected. 



Postviortevi appearance : — Locus inoculationis of nose show- 

 ed an indistinct cicatrization. Both kidneys showed multiple 

 herds grey white in color, hard and fibrous. Microscopically 

 they consisted of connective tissue, in which a few rudimentary 

 urinary tubes were visible. To the nature of this change we will 

 advert later on. No other change due to the inoculation. 



Case hi. 



Old bay mare of indigenous breed, observed from February 

 to May, '88. 



Clinical remarks : — Reduced condition. Some subcutaneous 

 nodes of walnut-hazelnut size on the breast, the right thoracic 

 wall along the spur vein, and on the xyphoid region. The 

 case was observed for some time, but neither progressive nor 

 regressive changes were recognized. Destroyed on May 7th 

 and dissected on the 8th. 



Postmortem appcaraiice : — The subcutis of breast, chest, and 

 xyphoid region showed nodules loosely connected with the sur- 



