I20 



in medullary swelling, but free from nodules ; the inter- 

 maxillary glands not at all affected. The Schneiderian 

 membrane on both sides covered with polypous or fungoid 

 new formations and ulcers of different size and shape, miliary, 

 linseed, pea to coin size, and partly hidden behind the turbinated 

 bones. The right false nostril entirely blocked up with such 

 new formations ; larger nodes showed partial softening. Sinus 

 and Eustachian valves and the remaining portion of tubus respira- 

 torius free from affection. The right testicle contained a 

 number of herds of pea-hazelnut size, having the same 

 appearance as subcutaneous nodules, quite circumscribed and 

 spherical in form ; the cut surface looked like that of round-cell- 

 sarcom : similar nodules also found in t2inica vaginalis communis 

 and epididymis. The left testicle contained only 2 nodules, 

 while the epididymis was full of them. Remaining internal or- 

 gans and articulations free from affection. 



Microscopically we found in the preparation stained with 

 Loeffler s methylene blue, granular aggregations, which were, as 

 later on ascertained, the grains of saccJiaromyccs. 



Ciiltnrc experiment on the potato pudding was negative. 



Inoculation of guinea pigs : 



Guinea pig No. l inoculated on June 1 5th with nasal discharge. 

 On the next day, observed a strong local inflammatory reaction, 

 weakness and lessened appetite ; inoculated part distinctly 

 swollen. From the 3rd day the swelling graduall)^ decreased 

 and the animal became more active. On the 5th day the animal 

 was destroyed, and autopsy revealed local suppuration and slight 

 enlargement of plica gland. No internal change. 



Male guinea pig No. 2 similarly inoculated. At first, the 

 symptoms were the same as in No. I. Complete recovery on 

 July l8th (33 days after inoculation). 



On June l6th the following guinea pigs were inoculated ; — 



No. 3 with the nodule of testicle. 



No. 4 and 5 with the new formation of nose. 



No. 6 with the hyperaemic lung tissue. 



These 4 guinea pigs reacted nearly in the same way as in No. 

 2 ; the lymphatic glands were distinctly swollen, but no abscess 

 was formed. 



