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was affected and thenceforth the condition more or less 

 reduced. Status praesciis ; — medium condition ; polypous or 

 fungiform nodes (1-3 cm. heigh) on dorsum nasi and at the 

 inner angle of the right eye ; they were hard and painful 

 to the touch. Many the same eruptions scattered over the in 

 ferior border of neck, anterior breast, lower part of lateral wall 

 of chest, shoulder, back, hip, right flank, &c. From the right 

 nostril discharge of greyish transparent fluid, and in the depth 

 of this cavity an elongated ulcer 2"5 cm. long and i cm. 

 broad, covered with a yellowish white crust ; on removing 

 the latter many irregular granulations in the bottom of the ulcer 

 visible. 



Postmortem appearance : — Characteristic ulcerative changes 

 in the Schneidcrian membrane on both sides of nose ; many 

 nodular herds in testicles, and some metastatic abscesses in 

 the liver. Lymphatic glands free from affection. 



Inoculation of guinea pig No. 27, with ulcerative tissue of 

 nose. On July ist (2nd day) locus inoculationis red and swollen ; 

 July 2nd (3rd day), the plica gland swollen to pea size. 

 July 15th (I6th day), scrotum together with the left testicle 

 (inoculated side) distinctly sAvollen. July 19th (20th day), the 

 swollen testicle no longer dislocable. July 22nd (23rd day), the 

 testicle was more swollen attaining the size of a hazelnut, painful 

 and showing partial fluctuation. July 28th (29th day), the animal 

 destroyed and dissected. Necropsy revealed a suppurative 

 destruction of the anterior half of the left testicle, forming an 

 abscess of hazelnut size; swelling and partial suppuration of 

 the plica gland, and one miliary nodule in the spleen. 



Culture experiment: — On potato pudding, which had been 

 infected with the content of the testicle-abscess from the guinea 

 pig No. 27, appeared, after 48 hours, a white zone around the 

 inoculation, and on the 4th day the latter showed a reddish brown 

 color. On the 6th day a distinct vegetation of a reddish brown 

 colony appeared, which became gradually prominent and at the 

 same time spread over the surface of the medium, and on the 

 18th day the colony attained a horizontal dimension of 3 cm. 

 The same culture was again obtained from the content of the 

 glandular abscess. By recultivation on fresh medium, the 

 vegetation became easier and more vigorous ; thus, the 2nd gene- 

 ration showed a distinct vegetation on the 3rd day, and the 3rd 



