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shoulder. On the 2nd day temp. 38.6°C., pulse 45, resp. 20 ; local 

 symptoms similar to the preceding. On the 3rd day temp, 

 40.2°C. ; purulent discharge from the nose and skin wound ; in- 

 termaxillary gland swollen. On the 4th day temp. 39.i°C. On 

 the 5th day temp. 38.8°C., pulse normal, respiration a little 

 difficult ; /ecus inociilatioiiis of shoulder much swollen ; ulcera- 

 tion in the mucosa of nose, and appetite diminished. On the 7th 

 day the cutaneous swelling a little reduced, while adjacent 

 lymphatics were swollen to finger size, leading from the in- 

 oculated focus up and downwards ; intermaxillary glands swollen 

 to thumb-size. On the lOth day 5 nodules appeared at the 

 anterior border of neck and many ulcerative nodes of pea-hazelnut 

 size, at the margin of the right nostril. Soon destroyed for 

 dissection. 



Postmortem appearance :~]^ocdi\ suppuration and ulceration. 

 I.ymphatics on the right shoulder in suppuration. Changes in 

 tlie nose and intermaxillary gland similar to the preceding. 



Young stallion of Japanese breed No. 5. Inoculated in the 

 same way as No. 4. On the loth day destroyed for dissection ; 

 nearly the same changes as the preceding. (As these experiments 

 had been conducted in Sendai and discontinued for want of time, 

 further observation was impossible.) 



Old stallion of Japanese breed No. 6, inoculated with 

 pure culture on Sept. 19th on the right side of septum nasi and in 

 the subcutis of the left thorax. 2nd day (after inoculation), locus 

 inocitlaiionis of thorax was swollen and painful ; the nasal 

 wound was covered with a yellow crust ; no abnormal dis- 

 charge. 5th day, bloody purulent discharge from the thoracic 

 wound ; a big ulcer appeared at the locus inocjilationis of nose, 

 and the intermaxillary gland a little swollen. 6th day, the 

 ulcer of nose getting larger and both alae nasi swollen. 

 8th day, the thoracic swelling more extended, and a cord-like 

 swelling appeared over the shoulder ; nasal ulcer much more 

 enlarged ; from both nostrils discharge of stinking, purulent 

 mucous fluid ; left anterior fetlock swollen, and hind quarters 

 Aveak ; death on the lOth day after inoculation. 



Postmortem appearance : — Condition bad and anaemic. At 

 locus inoculationis of thorax an abscess filled with thin 

 ichorous pus, from this abscess a varicose swelling leading 

 forwards over the shoulder. In the mucous membrane of the 



