I30 



septum nasi and turbinated bones of the right nose cavity, 

 numerous miliary to pea-sized ulcers, each surrounded with a 

 hyperaemic or haemorrhagic zone, the bottom looking yellowish 

 and lardy. In the lungs numerous nodes of pea-hazelnut 

 size, each node looking greyish yellow, quite circumscribed 

 and round in shape ; the superficial nodes surrounded with 

 a red or blackish red zone. The mucous membrane of trachea 

 and larynx hyperaemic. In the larynx coin-sized haemorrhagic 

 erosions, and in the trachea many small haemorrhages. The 

 subcutis of the right posterior fetlock with serous infiltration ; 

 the intermaxillary gland slightly swollen. 



5 guinea pigs (No. 33-37) inoculated with nodular hcj^ds of 

 the lungs from the stallion No. 6, 2 of them died, within 2 days, 

 from acute septicaemia, due to mixed infection with oedem 

 bacillus and streptococcus. The 3rd died on the lOth day with 

 symptoms of acute glanders. Postinortan revealed ulcerative 

 changes in the nose, ulcerative destruction of scrotum and 

 praeputium, and slight medullary swelling of plica gland. The 

 4th (No. 36) died 42 days after inoculation. Postmortem showed 

 ulcerative destruction of the local skin and subcutis, suppurative 

 herd in the plica gland and in the left testicle, and numerous 

 millet to pinhead-sized, grey white nodules in the spleen, liver, 

 lungs, and even in the pancreas. No. 37 (the 5th) died 62 days 

 after inoculation. Postmortem appearances were more con- 

 spicuous than in the preceding ; we found, besides local ulcerative 

 destructions, ulceration in the mucous membrane of nose, 

 formation of abscess in the inguinal, axillary and lumbar 

 gland, and grey white nodules in lungs, liver, and spleen. 

 From the guinea pigs (3rd-5th) pure culture of original bacillus 

 was obtained. 



An old stallion No. 7 inoculated, on July 1st, with pure culture 

 on the right side of nose and on the right shoulder. After 

 inoculation appeared a local suppuration. On Oct. 25th (115 days 

 after) the horse was destroyed and dissected. Postmortem : 

 a few nodules in the lungs. 



The same generation of the bacilli has repeatedly been in- 

 oculated in a great number of experimental animals. In the 

 course of time the virulency of the bacillus was gradually 

 weakened ; the reaction being mostly limited to the locus in- 

 oculationis. 



