'43 



This liorse received 3 injections of Mallcin. Tiic cutaneous 

 lesion was afterwards treated by Prof. Siito and the lesion 

 underwent some improvement, the saccharoinyces in the wound 

 secretion decreiisinf^ in number. Meanwhile a profuse purulent 

 discharge appeared from both nostrils ; respiration became 

 difficult ond d3'spnoc threatened. On June iSth tracheotomy 

 was performed, but it was of no avail to avert a quick 

 lethal termination of the disease. Autopsy was performed 

 on the igtli. 



Postniortciii appearance : — Long cicatrices on the left 

 scapular and thoracic region, and hard nodules of pea to 

 linseed size, 5-6 in number, on tlie perineum. In the right 

 testicle one metastatic Jierd of pigeon-egg size ; the inter- 

 maxillary glands not much enlarged, free from nodules. The 

 lungs full of circumscribed Jierds of hazel-nut size, round or 

 oblong and medullary on cut surface, and in both anterior lobes 

 the interstitial tissue distincth* thickened ; the remaining lung 

 tissue was partl}^ atelectatic and parth' oedematous with some 

 old thrombi in the branches of art. pulmonalis. No farcy changes 

 in the trachea, bronchi, and the lymphatic glands of chest. One 

 pea-sized nodule on the right side of septinn nasi. Micro- 

 scopically a few saccharoinyces were found in the Iicrd o{ the 

 lungs and testicle. 



Culture experiment of saccharojuyces on different media, 

 inoculation of guinea pigs (No. 83 & 84) and anto-inociilation 

 Avere negative. 



Cask x.wi. 



15ay stallion, 10 years old, purchased on Fcbruar)' lOtli. '93, 

 for experimental purjjoses. 



Clinical remarks : — Moderate nutrition ; a number of ulcers 

 found on the chest and left anterior and posterior e.xtrem.it}" ; 

 these idcers were of coin size, slighth' prominent over tiu skin 

 and covered with reddish yellow or brownish scabs. The left 

 intermaxillary gland a little swollen, but sinootli and dislocable. 

 Thin purulent discharge from the left nostril ; the Schneiderian 

 membrane, on this side, was covered with man\' small fungoid 

 ulcers. This horse received 3 injections of niallein. After 

 that the animal showed thick purulent and at times bloody 



