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testicle contained nodules of pea-walnut size, 5 in number ; 

 the intermaxillary glands on both sides a little enlarged and 

 partly turned to abscess ; the inguinal glands swollen to walnut 

 size and the cortical substance, on transection, grey white and 

 dim. Schneiderian membrane on both sides entirely destroyed 

 by ulceration, some ulcers being hollow, others prominent and 

 fungoid. A few ulcers were found in the mucosa of the pharynx, 

 larynx and of the upper part of trachea. In the thoracic 

 cavity we found pleuritis sicca and partial hepatization of anterior 

 lobes of lungs. 



Under the microscope we found, in tlie morbid parts, besides 

 saccJiaromyces, many coccen-like granules also collapsed and 

 semilunar saccJiaromyces , partly in pus corpuscles, and partly 

 free in the plasma. Long diameter of saccharoinyces 3.7 — 

 4.0 //., short diameter 2.4-3.2 ; the internal granule 0.5 //. 

 and free granule 1.0-2.0 a. The granules made an active 

 Brownian movement, strongly refracting the rays of light. The 

 free granules did not take any aniline stain ; they appeared like 

 micrococci or fat grains, probably tlie spores of saccJiaromyces. 

 In the lungs and pleural exsudation saccJiaromyces were absent, 

 we found tfipio- and streptococci. 



Culture experiment : — In this case we tried hanging drop 

 cultivation of saccJiaromyces with different fluid media, different 

 bouillons, hay infusion, horse dung infusion, with or witliout addi- 

 tion of pepton or of sugars, in alkaline or acid reaction. In those 

 to wliich pepton had been added, vegetation took place as early 

 as on the 7th day of cultivation. No vegetation observed in hay 

 infusion, horse dung infusion without pepton and with or without 

 grape sugar. In test tube cultivation with different fluid media, 

 which contained 2-4^ pepton in slight acid reaction, we noticed, 

 after 17 days, tlie vegetation of saccJiaromyces in the form of 

 granular precipitate ; the same vegetation was observed in simple 

 not neutralized beef and horse flesh bouillon. Under the micro- 

 scope the saccJiaromyces were in different formal modifications, 

 some being elongated to a kind of JiypJien. In common gelatine 

 medium, kept in room temperature, the vegetation appeared first 

 on the 56th day on the surface and along the inoculation-line in 

 the form of yellowish white sandy granules, prominent on the 

 surface ; there was no indication of liquefaction. The colony was 

 compact and not easily divisible. Microscopically we found even 



