153 



fr. anatomical characters be enumerated under the same category, 

 though actual statement on saccharoinyces was wanting. 



The next question is whether the usual saccharomycotic 

 farcy, met with in practice, is entirely free from malleous infection. 

 Here we must take into consideration the result of clinico- 

 anatomical observations and inoculation experiments in connec- 

 tion with bacteriological researches. C liuico-aiiatoinically , in 

 simple farcy in which no internal changes were found, there is the 

 least suspicion of malleous infection. As to those cases, how- 

 ever, in which metastasis was found in the internal organs, we 

 must be careful in deciding the question. As to jDulmonary 

 lesions, pleuropneumonia with caseous and hepatization herds 

 (XXIV, XXX), in which we found dipio- and streptococci, seems to 

 belong to Brust-seuche, which is very common in Japan. Chronic 

 indurative pneumonia, found in cases XX, XXV and XXXIII, is 

 undoubtedly the secondary change of saccharomycosis. Grey 

 nodules of sinapis to linseed size, found in cases Vlll, xvi, XVII 

 and XVIII, resemble malleous nodules, but the characteristic hy- 

 peraemic zone was wanting, and the nodules were mostly very few 

 in number ; further we could not prove the existence of bacillus 

 mallei. We sometimes find irregular calcareous nodules in the 

 lungs ; they are mostly the residua of catarrhal bronchitis or 

 of parasitary nature. Point-shaped multiple extravasations, 

 which were found in cadavers, destroyed for dissection, are 

 undoubtedly the result of disturbed circulation at the stage 

 of agony. Metastasis in the spleen and liver found in cases VI, 

 IX, XX and XXII appear to be of malleous nature : case IX was 

 true glanders ; In case XX inoculation failed to decide the nature, 

 while in cases VI and XXII, we were unable to prove the presence 

 of malleous bacilli. The herd of the kidney, observed in 

 cases II and III was anatomically a chronic interstitial 

 nephritis and appears to be of the same nature as the chronic 

 process found in the lungs. 



Result of inoculation : — In guinea pigs, inoculated with 

 morbid materials of farcy, we found nearly similar reactions, only 

 differing in intensity. Shortly after inoculation there was local 

 inflammatory swelling in different intensity either limited to locus 

 inoculationis or extending over the neighboring parts, praeputium, 

 scrotum, &c. ; these symptoms gradually passed away, and at the 

 end of the first week appeared a second group of changes; viz., the 



