i8i 



cliaroinycosis is curable in mm)' cases. Diat^nosis is more 

 surely ascertained by microscopical examination and by inocula- 

 tion. 



2. Inoculation : — Guinea pigs are sensible to the contagium 

 of true glanders ; for saccharomycosis they are, at least for 

 subcutaneous injection, entirely refractory. 



3. Mallein injection may serve for this purpose only by the 

 intensity of reaction. ]5ut as the reaction is very irregular, we 

 can scarcely depend on it. 



Special attention must be called to the fact that mixed 

 infection of saccharoniyccs and of B. mallei is not impossible. Ac- 

 cording to our experiments the contagiinn of true farcy may give 

 an opportunity for the development of saccharomycosis in faster 

 progression. Very important is the fact that the anatomical 

 picture in the case of mixed infection appears, according to our 

 observation, quite the same as in saccharomycosis. In such a 

 case differential diagnosis is very difficult, as microscopical 

 examination may easily lead to the misdiagnosis of a case. 

 Hence for exact diagnosis we must closely examine each 

 doubtful case in all directions as hitherto mentioned. 



ii. HiinusJii.'^^ 



Himushi is another skin affection, whicli is also common in 

 Japan, and whicli appears in farm horses exclusively in summer. 

 It is at first acute, and suddenly developes with strong inflam- 

 matory symptoms, resulting in an extended necrobiosis of cutis 

 and subcutis. Thus arises a big ulcer with exaggerated granula- 

 tion on the bottom and border of wound, combined with an 

 enormous thickening of the skin and subcutis. Then it assumes 

 a somewhat different aspect and is often liable to be confounded 

 with saccharomycosis. The following are cardinal points of 

 difference : — 



1. i'/^/ always appears in a single part of the body, and 

 is never disseminated. 



2. Himushi is very itching. 



3. Morbid changes of HimiisJii consist of connective tissue 



(I) Botiliy describcil one >kin disease of \\orse~ Dfr7?idiit( grannlcttsc or plaies 

 estivale, in which Rivolta h.is found a small nematode — Filaiia irritans. Whether 

 Himushi is similar to tliat disease or not is not yet decided. 



