CHEMISTRY: R. A. BUTCHER Proc. N. A. S. 
of Kendall's findings that energy production was dependent upon thyroid 
activity. Pilocarpine hydrochloride was used because of Uhlmann's 
work mentioned above. Tethelin, the growth-controlling principle of the 
anterior lobe of the pituitary body,^^ was fed for similar reasons. All 
of these substances produced definite relief and cessation of polyneuritic 
symptoms. The response was slower in all cases than when vitamines 
are fed. 
The hormones from the ductless glands undoubtedly influence to a 
marked degree the activity, health, growth and well-being of animals. 
May it not be possible that the hormone supply is dependent upon the 
vitamine content of the food? As a result of our observations, we wish 
to suggest tentatively that the activity of the organs of internal secretion 
are dependent upon the stimulatory action of the vitamine. Whether 
this is in the nature of a nerve stimulant, nuclear nutrient or the chemical 
nucleus of a hormone is, of course, a matter of speculation. 
1 Published with the approval of the Director, as Paper No. 185, Journal Series, 
Minnesota Agricultural Experiment Station. 
2 Eijkman, C, Virchow's Arch. path. Anat., 148, 1897 (523-532). 
3 Schaumann, H., Arch. Schiffs- und Tropen-Hygiene, 14, 1910 (325-721). 
* Voegtlin, C, and Myers, C. N., Puh. Health Rep., 33, 1918 (911-917). 
5 Green, H., S. African J. Sci., 14, 1918 (519-520). 
6 Funk, C, /. Physiol, 43, 1911 (395-400). 
7 Kdie, E. S., Evans, W. H., Moore, B., Simpson, G., Biochem. J., 6, 1912 (234-242). 
8 Suzuki, U., Shimamura, I., and Odake, S., Biochem. Zs., 43, 1912 (89-153). 
9 Schaumann, H., Arch. Schiffs- und Tropen-Hygiene, 16, 1912 (349-361, 825-837). 
10 Funk, C, /. Physiol., 45, 1912 (489-492). 
11 Williams, R. R., /. Biol. Chem., 25, 1916 (437-445). 
12 Williams, R. R., Ibid., 29, 1917 (495-520). 
13 Harden, A., and Zilva, S. S., Biochem. J., II, 1917 (172-179). 
14 Voegtlin, C., and White, G. F., /. Pharm. Expt. Ther., 9, 1916 (155-166). 
15 Williams, R. R., and Seidell, A., /. Biol. Chem., 26, 1916 (431-456). 
16 Funk, C, /. Physiol., 47, 1913; Proc. Physiol. Soc. (xxv-xxvi); Zs. physiol. 
Chem., 89, 1914 (373-377). 
17 Funk, C., and von Schonborn, E., /. Physiol., 48, 1914 (328-331). 
18 Funk, C, and Douglas, M., Ibid., 47, 1914 (475-478). 
19 Douglas, M., /. Path. Bad., 19, 1915 (341-348). 
20 Drummond, J. C, Biochem. J., 12, 1918 (25-41). 
21 Dutcher, R. A., /. Biol. Chem., 36, 1918 (63-72). 
22 Jackson, C. M., and Stewart, C. A., Minnesota Medicine, I, 1918 (403). 
23 Osborne, T. B., and Mendel, L. B., /. Biol. Chem., 18, 1914 (95-106). 
24 McCarrison, R., British Med. J., No. 3033, 1919 (177-); Ind. J. Med. Res., 6, 
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25 Uhlmann, F., Zs. Biol, 48, 1918 (419-456, 457^98). 
26 Kendall, E. C, Collected papers of the Mayo Clinic, 9, 1917 (S09-SS6) ; Endrinology, 
2, 1918 (81-). 
27 Dutcher, R. A., /. Biol. Chem., 39, 1919 (63-68). 
28 Robertson, T. B., Ibid., 24, 1916 (397-408, 409-421). 
