134 
GENETICS: GUYER AND SMITH 
Proc. N. a. S. 
TABLE 2 
Correlations in the Male Adult Series 
COEFFICIENTS OF CORREI.ATION 
CORRELATED MEASUREMENTS 
540 
Full-bloods 
77 
Half-bloods 
Stature and Sitting Height 
Stature and Width of Shoulder 
Stature and Arm Reach 
0.61 
0.35 
0.81 
0.70 
0.27 
0.55 
0.16 
0.05 
0.65 
0.48 
0.85 
0.76 
0.54 
0.51 
0.08 
0.02 
Stature and Length of Arm 
Length and Width of Head 
Width of Head and Width of Face. . . 
Anatomical Height and Width of Face 
Height and Width of Nose 
TRANSMISSION OF EYE-DEFECTS INDUCED IN RABBITS BY 
MEANS OF LENS-SENSITIZED FOWL-SERUM 
By M. F. Guyer and B. A. Smith 
Zoological Laboratory, University of Wisconsin 
Communicated by L. Hektoen, January 19, 1920 
As the work progresses it is becoming increasingly evident that the 
discoveries made in the field of serology all have their broader biological 
aspects, and that they afford new methods of attacking certain funda- 
mental biological problems. Not the least of these is a possible method 
of breaching the wall which has gradually come to surround the long- 
standing problem of provoking specific modifications in the germ-cell 
through the direct action of external agencies, or indirectly, through 
changes produced in the parental body. For if external influences can 
be transmitted to the germ-cell, the one obvious means of conveyance 
in higher animals is the blood, and when one considers the protean possi- 
bilities which modern work has revealed in the blood, it is certainly a 
rational quest to seek in this medium a possible means of altering the 
germ. To set the problem more specifically, if a serum of one species of 
animal can be so sensitized to a given tissue or tissues of another species 
that it will become toxic or lytic for the tissue in question, may it not 
be that there is sufficient constitutional identity between the mature sub- 
stance of the tissue and at least some of its material antecedents in the 
germ, that the latter may also be influenced specifically by the sensitized 
serum? Or may not changes in its own tissues originate antibodies in 
the blood serum of a given individual which will not only react with the 
tissue elements themselves but with their correlatives in the germ cells? 
In an attempt to find answers to these and kindred questions we have 
been engaged in series of experiments which have extended over a period 
