136 PATHOLOGY: BARBOUR AND HERRMANN Proc. N. A. S. 
As already mentioned, once the defect is secured, it may be transmitted 
to subsequent generations through breeding. So far we have succeeded 
in passing it to the sixth generation. There seems to be no reason why it 
will not go on indefinitely since the imperfection tends to become worse 
in succeeding generations and also to occur in a proportionally greater 
number of young. The transmission was not infrequently of an irregular 
unilateral type, sometimes only the right, at others only the left eye 
showing the defect. In later generations there was an increasing number 
of young which had both eyes affected. 
To meet the objection that we were not getting instances of true in- 
heritance in each generation but merely placental transmissions of anti- 
bodies or kindred substances from the blood stream ol the mother, it was 
obviously necessary to establish the descent through the male line alone. 
To do this females from strains of rabbits unrelated to our defective-eyed 
stock were mated to defective-eyed males. The first generation produced 
in this way were invariably normal-eyed, but when females of this genera- 
tion in turn were mated to defective-eyed males the defect reappeared 
in some of the progeny somewhat after the manner of an extracted Men- 
delian recessive. Inasmuch as the defect can thus be made to reappear 
in the descendants of a male with abnormal eyes when he is mated to a 
female from unrelated and untreated stock, it is obvious that it could only 
have been conveyed through the germ-cells of the male, and that it may, 
therefore, be pronounced an example of true inheritance. 
The detailed study, with charts, pedigrees, drawings and photographs 
will appear shortly in the Journal of Experimental Zoology. 
ON THE MECHANISM OF FEVER REDUCTION BY DRUGS 
By Henry G. Barbour and Julian B. Herrmann 
Department of PharmacoivOgy, Yale University, School of Medicine 
Communicated by L. B. Mendel, Read before the Academy, November 10, 1919 
Correlation of antip)rretic drug action with the carbohydrate metabolism 
has been suggested by one of us^ as a result of two findings in fever patients. 
In the first place dextrose by mouth has been found frequently to exert a 
mild antipyretic action; on the other hand, acetyl-salicylic acid or anti- 
pyrine under similar conditions increase the respiratory quotient, thus 
indicating a relatively augmented carbohydrate combustion. These 
facts point strongly to a mobilization of sugar by such drugs. 
We have, therefore, investigated the effects of antipyretics upon normal 
and fevered dogs with particular attention to the concentration of dex- 
trose in the blood. Mild fever was produced by the subcutaneous in- 
jection upon the preceding day of a suspension of killed colon bacilli. 
Doses of from 0.2 to 0.5 gram, per kilo of the following drugs were given : 
sodium salicylate, quinine hydrochloride, antipyrine (all subcutaneously) 
