Vol.. 6, 1920 PATHOLOGY: BARBOUR AND HERRMANN 
137 
and acetyl-salicylic acid (per os). In fevered dogs a fall in body tempera- 
ture of about 1° C. resulted; on the other hand a slight increase was the 
only observed change in the temperature of normal animals. 
70 
0.2 
0.1 
I I I I I I I I I I 
Doq H 13 (Normal) 
0.5 0 m. p.A-. 
% 
ISO 
100 
U 12 I Z 3 
Fig. 1. Kffects of acetyl-salicylic acid (0.5 gm. per kilo) on normal dog. Rectal tem- 
perature: light line; blood dextrose per cent: broken line; hemoglobin per cent: 
heavy line. 
f Blood Dextrose. — Both series of dogs were subjected to investigation 
of the blood sugar concentration by the Benedict-Lewis method. In all 
animals irrespective of the fevered condition there resulted a moderate 
hyperglycaemia, the extent of which may be judged from the following 
summary : 
Dextrose Concentration in the Blood 
BEFORB ANTIPYRBTIC 
MAXIMUM AFTER ANTIPYRBTIC 
% 
% 
Average of 13 normal dogs 
0.137 
0.186 
Average of 10 fevered dogs 
0.139 
0.218 
Blood Volume. — ^The hemoglobin concentration was followed in most 
of these experiments simultaneously with the blood sugar, employing the 
colorimetric method of Cohen and Smith. ^ In the normal dogs was found 
a rise in the hemoglobin percentage accompanying the slight temperatiu-e 
increase. The thickening of the blood thus indicated was insignificant 
in comparison with the observed dextrose increase, the latter being thus 
proven absolute rather than merely relative. 
Fevered dogs, on the other hand, showed a distinctly increased blood 
volume as indicated by the diminished hemoglobin percentage accompany- 
ing the antipyretic effect. Dilution of the blood of fever patients by 
acetyl-salicylic acid and by antip3n:ine has also been observed by one of us. 
