104 Pr. Beale, on Intercellular Substance of Cartilage, 
many separate splierical masses of living matter results. A 
space may thus be scooped out in the compact tissue of bone, 
and the process may go on until what is termed an abscess 
results. Very rapid growth is associated with the formation 
of a soft, spongy, and short-lived tissue; very slow growth 
with the production of a very hard and lasting structure. 
But in all cases the active changes are dependent upon the 
existence of living matter, that is, matter in which certain 
phenomena can be observed or proved to occur, which can- 
not, in the present state of science, be explained by physics or 
chemistry, and which never do occur except in matter derived 
from a living being. 
