54 Dr. BealEj on the Germinal Matter of the Blood. 
"Now J the evidence in favour of the view that these are 
entirely derived from the normal cells connected with the 
pulmonary tissue^ is_, to say the leasts very unsatisfactory, 
while many facts seem in favour of the conclusion that they 
are developed in the exuded plasma. 
In certain conditions of the kidney a quantity of clear and 
perfectly transparent coagulable material is poured out into 
the uriniferous tubes and coagulates there ; now I have seen, 
in the very centre of this coagulum, small granular " cells in 
process of increase. Erom what ^^cell proliferation^^ could 
these bodies result? (See 'Archives of Medicine/ vol. ii, 
page 286) ; also ' Urine, Urinary Deposits, and Calculi,^ 2nd 
ed., p. 68.) 
Again, in many cases are found delicately granular cells 
and corpuscles external to the vessels, and amongst the so- 
called connective-tissue-corpuscles and their prolongations. 
The connective-tissue-corpuscles are not enlarged, nor do they 
exhibit any irregularities, so that it seems to me unreasonable 
to assume that the granular corpuscles were formed in the 
connective-tissue- corpuscles and then set free, as some would 
assert. 
I have thus been led to entertain views different to those 
already advanced, and I think the inferences I have deduced 
will serve to explain satisfactorily facts which are opposed to 
the cell doctrine, but which certainly cannot be explained by 
the exudation theory. 
When the capillary vessels are distended as in that extreme 
congestion which soon passes into inflammation, a fluid which 
possesses coagulable properties transudes through the stretched 
capillary walls. It is probable that in such cases minute and 
narrow fissures result, which, however, are too narrow to 
allow an ordinary white or red blood-corpuscle to escape, 
but nevertheless wide enough to permit many of the 
minute particles of living or germinal matter (the existence 
of which in the blood has been already referred to), to pass 
through. The small protrusions upon the surface of the 
white blood-corpuscles might grow through the capillary 
walls, become detached, and pass into the tissue external to 
the vessels. Such minute particles of living matter external 
to the vessels being surrounded with nutrient pabulum, and 
stationary, would grow and multiply rapidly, while a similar 
change would of course go on in the now stagnant fluid in 
the interior of the capillary. The result would be exactly 
that which is actually observed, viz., the presence of a vast 
number of cells like white blood- corpuscles in the interior of 
the capillary vessel and immediately around its external sur- 
