Dr. BealEj on Sarcolemma. 
101 
connective tissue are represented by the connective tissue 
between the bundles of tendinous fibres. The nuclei of the 
muscle correspond to the nuclei of the tendon^ the contractile 
tissue to the fibrous tissue. That this is so^ is clearly proved 
by the fact that the contractile material of muscle may 
degenerate into a tissue which is continuous with,, and cannot 
be distinguished from, the original normal tendon. 
There are, then, many cases in which the nuclei of the 
intermuscular connective tissue appear as if they were nuclei 
of the sarcolemma^ and cases in which nuclei, originally 
belonging to the contractile tissue, in consequence of the 
wasting of the latter, appear to be imbedded in the thickened 
sarcolemma. 
In order, then, to account for the nuclei in the sarcolemma 
which belong neither to the nerve-fibres, nor the vessels, nor 
the intermuscular connective tissue, it is necessary to pass in re- 
view somewhat more in detail certain facts observed in studying 
the development of muscle. I have shown that in the deve- 
lopment of a bundle of nerve-fibres the nuclei in the interner- 
vous connective tissue (the so-called nuclei of the tubular mem- 
brane) have descended from the same original nuclei which 
gave origin to those concerned in the production of the true 
nerve-fibres. Or, in other words, that of the total number of 
nuclei (masses of germinal matter) which result from the 
division of the original nuclei, some take part in the develop- 
ment of true nerves while others produce connective tissue. 
And where dissimilar structures are developed in close 
relation with one another — as, for example, where a nerve- 
trunk and vessels are developed ^an^oj^^M in close proximity — 
there exists between them a certain proportion of indefinite 
connective tissue. The origin of the tissue in this neutral 
territory is obscure, but there can be little doubt that the 
nuclei present are in part the descendants of those which 
were concerned in the production of the nerve-fibres, and in 
part of those which were concerned in the development of 
the vessels. The same view will explain the origin of the 
connective tissue and its nuclei between the glandular ele- 
ments and the vessels of glands, and other cases in which 
indefinite connective tissue intervenes between, and is said to 
connect together, dissimilar structures; it being an un- 
doubted fact that in the development of these textures the 
masses of germinal matter first produced are forced to the 
outside by the formation of new masses within. The latter 
are instrumental in the development of the special structure, 
while the former are concerned in the production of the in- 
definite tissue (connective tissue) which invests this last. So it 
